Senior Scientist, Biochemistry and Quantitative Pharmacology-Enzymology (non-PhD)

La Jolla, California
September 25 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that improve patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose where we translate science and technologies into the therapies and vaccines that matter most. Whether you are in discovery, ensuring drug safety and efficacy or supporting clinical trials, you will be a key contributor to our mission of bringing best in class medicines to patients around the world.

What You Will Achieve

The Oncology Research Division in La Jolla, California is seeking a motivated and innovative Senior Scientist (BS/MS level) to join the Biochemistry and Quantitative Pharmacology-Enzymology group within Discovery Technologies. The successful candidate will provide their expertise in mechanistic biochemistry/enzymology to enable the advancement of pre-clinical programs within the Pfizer Oncology portfolio. They will gain in-depth, hands-on experience with cutting-edge drug discovery strategies from concept to clinical candidate nomination on diverse targets ranging from kinases, non-kinase enzymes, and other challenging proteins relevant to cancer.

How You Will Achieve It
  • Conduct high-quality, properly controlled experiments with an emphasis on rigor and reproducibility
  • Perform mechanistic analyses of key project compounds
  • Identify and execute innovative screening strategies using internal and external knowledge
  • Develop, optimize, and validate robust plate-based biochemical assays suitable for screening and SAR
  • Collaborate within the group and across project teams to enable the identification and advancement of promising drug candidates to the clinic
  • Participate and present results at project meetings and other internal, external meetings
  • Communicate results precisely in both written and oral formats


  • Bachelor of Science degree in Biochemistry or related discipline with 8+ years relevant post-graduate experience or MS degree with 6+ years of experience
  • Experience in biochemistry, including enzyme kinetics and protein-ligand interactions
  • Documented experience in biochemical assay development, providing SAR support
  • Experience with data analyses and management
  • Excellent organizational skills with outstanding verbal and written communication
  • Ability and desire to effectively collaborate within a matrixed and diverse environment
  • Strong self-motivation, can work independently and within a team
  • Positive and enthusiastic attitude with the desire to help others
  • Interest in expanding their own scientific knowledge and skills
  • Experience in managing and coordinating internal and external resources to achieve project objectives

  • Strong interest in evaluating and implementing new technologies
  • Extensive scientific knowledge on a specific area of emphasis for Pfizer Oncology (e.g., Cell Cycle, Cancer Immunology, etc.)

  • Ability to execute laboratory experiments and perform complex data analyses
  • Ability to interpret results relative to published data and ongoing Pfizer programs
  • Strong interpersonal skills and a desire to succeed in a team setting

  • Last Date to Apply: October 7th, 2021

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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