Scientist (non-PhD), T Cell Biology

La Jolla, California
September 25 2021
Position Type
Full Time
Organization Type

The Cancer Immunology Discovery group at Pfizer is seeking a highly motivated and creative Scientist to join the T cell activation and PDx resistance team to identify and evaluate novel therapies in the fields of Cancer Immunotherapy. The successful candidate will have expertise in T/NK cell biology, the tumor microenvironment, target validation and a track record of success in immune-oncology drug discovery. The candidate will work in a fast-paced and highly collaborative environment. S/He is expected to conduct bench work, keep up with relevant research field, and move drug development via interactions with cross-function groups.

  • Discover and develop new therapeutic modalities for cancer immunotherapy targeting T cells or NK cells.
  • Design and execute in vitro cell line or primary cell based experiments and optimize the assays for antibody drug candidate screening.
  • Execute mechanistic, PD, and biomarker studies for preclinical-stage therapies using in vivo mouse models and ex vivo assays, including but not limited to multi-parameter flow cytometry, target expression analysis and functional assays.
  • Collaborate with protein engineering, translational pharmacology, PK/PD, toxicology, computational biology, and clinical development group to pursue the most promising drug candidates.
  • Participate and present in internal and external project meetings as well as at site and cross-site meetings.
  • Record experimental protocols/results in detail and write technical reports for regulatory filings.

  • BS/BA with 5+ years of experience or MS with 3+ years of experience.
  • Experience in development of antibodies/bispecifics targeting T cells or NK cells.
  • Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, and/or proliferation by using T cells or NK cells).
  • Experience with flow cytometry (Fortessa and/or Cytek Aurora), ELISA, MSD, reporter assays or cytotoxic assays (CTG and/or LDH assays).
  • Ability to plan and execute in vitro experiments with minimal supervision.
  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic.

  • Previous industrial experience and knowledge of drug discovery.
  • Proficiency in high-parameter immune phenotyping of immune cells (isolated from mouse and/or human tissues) by Flow Cytometry (comfortable running at least 10-color panels, including intracellular staining).
  • Experience in assessing T cell and/or NK cell function, differentiation, and memory development.
  • Experience with various murine tumor and/or infectious disease models.

  • Standing, sitting, bending, lifting, walking in a laboratory setting.
  • Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory.
  • Standard business office conditions; sitting, standing as appropriate.

Other Job Details
  • Eligible for Employee Referral Bonus

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development