Senior Principal Scientist, Process Chemistry

Groton, Connecticut
September 25 2021
Position Type
Full Time
Organization Type

We are seeking a synthetic organic chemist to join the Process Chemistry group within Chemical Research and Development (CRD) in Groton. CRD, as part of Worldwide R&D in Pharmaceutical Sciences, is responsible for the development of process technology for the production of active pharmaceutical ingredients (API). CRD scientists engage in all facets of development from small scale synthesis in support of Discovery programs, to the development of the commercial synthetic route. CRD scientists partner with manufacturing specialists for API synthesis in kilo-lab and pilot plant facilities, as well as provide support for technology transfer to Pfizer manufacturing sites and third party facilities.

The Senior Principal Scientist will design, enable and develop scalable processes to pharmaceutical drug candidates, applying innovative chemistries, new technologies and statistical experimental design approaches. The ability to work on and lead multi-disciplinary teams involving chemists, analysts, engineers, and technologists, and to represent CRD on cross-functional teams is essential. The candidate is also expected to be an expert in the field with a strong reputation in the area of process chemistry and a track record of innovation and portfolio delivery.

  • The successful candidate would propose and identify efficient and robust synthetic routes for the preparation of API's.
  • This position requires laboratory experimentation, leadership on API project teams and close collaboration with scientists from Analytical R&D and other disciplines to further develop synthetic routes into safe, efficient and robust processes.
  • Interpretation of analytical data to drive synthetic experimental plans and the ability to utilize tools such as electronic notebooks to document information are essential.
  • A desire to continue to develop and apply new skills is required.
  • The successful candidate would also be responsible for participating in the preparation of technical transfer documents for manufacture internally or at third parties.
  • The successful candidate would lead API project teams, represent CRD on cross disciplinary programs within Pharmaceutical Sciences and contribute to departmental initiatives.
  • A strong working knowledge of current Good Manufacturing Processes (GMP) is desired. Compliance on safety and regulatory requirements is expected and documented through our internal training program.
  • The successful candidate would also participate or lead key initiatives for CRD and contribute to continuous improvement work in the department and advancement of the Process Chemistry discipline through technology, workflow or business impact.

  • PhD. in Organic Chemistry, with 7-12 years of pharmaceutical R&D experience in Process Chemistry required.
  • State of the art knowledge of modern synthetic methodology, including aspects of asymmetric synthesis, green chemistry, catalysis and physical organic chemistry as it relates to reaction mechanism is expected.
  • Ability to employ analytical tools, computational and statistical methodology, and automated laboratory technologies to enhance process development efficiency is desirable.
  • Excellent written and oral communication skills, the ability to effectively influence the work of others
  • General knowledge of drug development and the pharmaceutical industry are key.

  • Laboratory work requiring standing.
  • Working at a computer.
  • Ability to use sound scientific judgment and analyze data to advance programs.
  • High emotional intelligence and self-awareness.

  • Travel is required on occasion in support of external manufacture or to participate in scientific conferences.

Please submit a copy of your CV/resume, research summary along with a cover letter for consideration.

  • Eligible for relocation support
  • Eligible for employee referral bonus


Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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