Postdoctoral Fellow - Cancer Genetics/Epigenetics

Monrovia, California
September 23 2021
Position Type
Full Time
Organization Type
About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

Seeking a Postdoctoral to join the lab of Dr. Chun-Wei (David) Chen in Systems Biology focused on the epigenetic mechanisms underlying the therapeutic resistance in cancers. This laboratory is skilled in high-throughput CRISPR genetic screens for de novo therapeutic target discovery. They also utilize next-generation sequencing (NGS) for epigenomic and transcriptomic analyses (ChIPseq, ATACseq, RNAseq, etc.), and the patient-derived xenograft (PDX) models for in vivo therapeutic efficacy assessments. In addition, Dr. Chen's laboratory is involved in cutting-edge technology development including high-density CRISPR protein scan, precision epigenome editing, and single-cell CRISPR/RNA-seq. The lab is well funded by several NIH (R37 MERIT, R01s, U54) and foundation (ASH, LLS, ALSF, COSF, SU2C-CRUK) awards.

Basic education, experience and skills required for consideration:
  • A Ph.D. degree in biomedical sciences, structural biology, computational biology or bioinformatics (required).
  • Good oral and written communication skills in English (required).
  • Experience in cell biology, molecular cloning, or animal model studies (highly preferred).
  • Experience in transcriptomic, proteomic, epigenetic, molecular dynamic, or protein structural data analysis (highly preferred).
  • Experience in protein purification, compound screen, protein/protein or protein/compound interaction (highly preferred).
  • Experience in R, Python, Perl, UNIX/LINUX, etc. (highly preferred).

Additional Information:
  • For more information about Dr. David Chen's research, please click here.
  • List of recent publications, please visit here .
  • To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


  • Posting Date: Jul 26, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job

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