Molecular Clinical Variant Curator

Location
Duarte, California
Salary
Competitive
Posted
September 22 2021
Ref
10010553
Position Type
Full Time
Organization Type
Healthcare/Hospital
About City of Hope

***Please note, this is not a remote position***

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

The Clinical Variant Curator assists the clinical and developmental operations of the Clinical Diagnostic Molecular Genetics Laboratory (CMDL) to accurately identify and precisely classify variants/mutations detected through standard molecular genetic testing.

Duties include assisting clinical laboratory leadership as a resource for ongoing test development and clinical testing pipelines in conjunction with the interpretation and classification of genetic variants.

Key Responsibilities include:
  • Use comprehensive knowledge of scientific theory and departmental policies and procedures to curate genetic variants/mutations detected through standard molecular genetic testing using information from existing databases and from literature.
  • Participate as a productive member of the work team.
  • Maintain continued involvement in professional development through participation in educational opportunities to ensure continued adherence to standards and provision of quality laboratory care.
  • Follow policies/procedures/regulatory requirements and perform other work assignments.
  • Curate genetic variants/mutations applicable to the CMDL offerings.


Basic education, experience and skills required for consideration:

Minimum Education:
  • Master's Degree in Biological Sciences and familiarity with Germline databases, Sanger Sequencing and Next-generation sequencing (NGS) or Bachelor's Degree and familiarity with Germline databases, Sanger Sequencing and Next-generation sequencing (NGS) and 2 years of sequencing data interpretation.


Minimum Experience:
  • Knowledge of principles and practices of computational biology as applied to genetics/genomics. An understanding of bioinformatics analysis to identify variants within genomic data sets, and variant effect prediction algorithms. Laboratory and/or clinical experience in cancer genetics. The ability to critically read, understand, and interpret data from scientific publications. Cross-disciplinary and strong analytical skills as well as broad experience using computational methods, databases, software and hardware.


Preferred Experience:
  • 2 years of sequencing data interpretation is desirable with Master's Degree in Biological Sciences.


City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

  • Posting Date: Sep 22, 2021
  • Job Field: Allied Health
  • Employee Status: Regular
  • Shift: Day Job

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