Principal Scientist (Director), Drug Metabolism and Pharmacokinetics

Principal Scientist (Director), Drug Metabolism and Pharmacokinetics
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gileads therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the companys five core values. Thats because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

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Gilead Sciences, Inc. is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead's therapeutic areas of focus include HIV/AIDS, liver diseases, serious respiratory and cardiovascular conditions, cancer and inflammation, headquartered in Foster City, California.

Gilead's core values of integrity, inclusion, teamwork, excellence, and accountability shape our culture and are the foundation of our future success. Challenge yourself and make a difference in the world - Being Here Matters.

Specific Responsibilities:

The primary responsibility of this Drug Metabolism and Pharmacokinetic (DMPK) scientist is to serve as a DMPK representative and lead a group to investigate the intracellular metabolism and transport of nucleoside analogs. This job role will focus on providing guidance to drug discovery project teams, defining candidate selection strategies, and continue through drug development phases to registration/post approval.

Essential Duties and Job Responsibilities:

• Work closely with internal and external resources to assure high quality and timely delivery of nonclinical and clinical PK-ADME data for molecules in discovery and development.
  
• Design and perform complex analysis to characterize intracellular metabolism, transport and disposition of nucleoside analog drugs.
  
• Serve as DMPK subject matter expert on dynamic cross-functional teams, provide in vitro and in vivo drug disposition data, interpretation and presentations to teams.
  
• Able to communicate and educate others on complex areas of PK-ADME as a technical expert.
  
• Supervising associate and research scientists may be needed.
  
• Make major contributions to scientific literature and conferences through publication and presentation of research results.
  

Knowledge, Experience and Skills:

• Requires a highly motivated individual with a PhD degree in biology, biochemistry, pharmaceutical sciences or related area with 10+ years of industry experience.
  
• Prior experience contributing to the discovery and development of drug candidates from preclinical through clinical trials.
  
• Be a subject matter expert in cellular uptake intracellular metabolism, elimination, human dose projection and metabolite identification of nucleoside analog drugs demonstrated through presentation/publication record.
  
• Provide oversight and integration of the data and data-reports, proactively manage to resolve data gaps, and address regulatory inquiries.
  
• Comfortable working with and educating colleagues in drug metabolism, toxicology and clinical pharmacology on strategies to understand the PK-ADME.
  
• Demonstrates excellent scientific verbal, technical communication and interpersonal skills. Must be organized, pay attention to details and have strong planning skills.
  

For jobs in the United States:
As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans\' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the EEO is the Law' poster.

NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT
YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT

PAY TRANSPARENCY NONDISCRIMINATION PROVISION

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:
Please log onto your Internal Career Site to apply for this job.
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To apply, visit https://gilead.wd1.myworkdayjobs.com/en-US/gileadcareers/job/United-States---California---Foster-City/Principal-Scientist--Director---Drug-Metabolism-and-Pharmacokinetics_R0020883-2





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