Senior Scientist, Protein Crystallographer

Boulder, Colorado
September 10 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist

We are seeking a highly motivated Senior Scientist-level protein crystallographer with strong expertise on X-ray crystallography to join the Structural Biology group at Pfizer-Boulder Research and Development Unit. The successful candidate will apply a broad range of structural biology tools to determine high resolution ligand-bound protein structures to support our Structure-based drug discovery programs.

Pfizer Boulder Research and Development is focused on the discovery, development, and commercialization of small molecule drugs to treat cancer patients. Based in Colorado, with more than 300 days a year of sunshine, Boulder is a paradise in the West! Visit to discover what we love about Boulder.

  • Grow diffraction-quality ligand-bound protein crystals for both novel and well-established targets.
  • Design and conduct protein crystallization trials, crystal optimization, and X-ray data collection using both in-house X-ray generators and remoted data collection on synchrotrons.
  • Solve and refine structures either by Molecular Replacement or de-novo
  • Perform E. coli growth and recombinant protein expressions at liter-scale
  • Establish purification protocol and purify recombinant proteins from source cells
  • Document experimental data and communicate research priority, progress, and results with project teams.
  • Contribute to written and oral presentations related to research findings.


  • PhD in structural biology or a related field having 0-2 years' postdoctoral experience in industrial or academic research
  • Mastered protein X-ray crystallography from crystallization, optimization, data collection and processing, to structure determination proven by a track record of publications as the key contributing crystallographer/author in reputable, peer-reviewed journals.
  • Experience with current software package for model building and refinement such as Phenix, Global Phasing, CCP4, Chimera, Rosetta, Coot.
  • Experience with crystallization robot and AKTA purifier system and standard analytical techniques associated with assessing protein quality during the purification process.

  • Experience to use integrated biophysical and structural biology experiments to understand interactions between small molecules and macromolecular target.
  • Experience with in-house X-ray generator operation and maintenance.
  • Experience with cryo-EM sample preparation protocols and data collection.

  • Able to lift 50lb objects with dimensions 12 inches in height and 26 inches in width
  • Able to visualize microscopic objects under microscopes

  • Able to adhere to safe work practices and perform lab works with appropriate personal protection equipment such as but not limited to safety goggles, facial mask, gloves, lab coat/ protective gowning, and closed toe shoes
  • Able to work at flexible hours occasionally when performing time-sensitive experiments

Other Job Details

Eligible for Relocation Package

Eligible for Employee Referral Bonus

For roles based in Colorado:

The annual base salary for this position ranges from $80,000.00 to $133,300.00. In addition, this position offers an annual bonus with a target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

Similar jobs

Similar jobs