GSK

Scientist in Protein Biochemistry and Crystallography

Employer
GSK
Location
Rockville, MD
Salary
Competitive
Posted
September 10 2021
Ref
298880
Organization Type
Pharma
Site Name: USA - Maryland - Rockville Posted Date: Sep 10 2021 As a Scientist in the Structural Biology Lab in the Preclinical Department of GSK Vaccines (Rockville, Maryland), you will be responsible for 3D structural characterization and analysis of candidate vaccine antigens and antibodies. This group plays an essential role in supporting preclinical, development and life-cycle management projects at GSK Vaccines. We are looking for a highly motivated scientist, with a proven track record in the most relevant areas of x-ray crystallography, high throughput screening, protein expression, protein biochemistry, and protein engineering, in order to provide expertise in vaccine development for GSK projects. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Degree in structural biology, biochemistry, biotechnology or related field. PhD with 0-2+ years of experience, MS with 5+ years of experience, or BS degree with 10+ years of experience. Experience in protein x-ray crystallography, including high throughput crystal screening and crystal optimization. Experience with crystallography software for data processing and visualization (HKL, Phenix, XDS, Coot, Pymol, Chimera, CCP4). Experience with diverse protein purification methods (e.g. affinity column purification and size exclusion chromatography) and equipment (e.g. AKTA avant systems). Experience with in bioanalytical and biophysics assays (e.g. SDS-PAGE, Western blot, SPR, DSF, DLS). Preferred Qualifications: If you have the following characteristics, it would be a plus: PhD degree with focus on X-ray structural analysis of antigen-antibody complexes. Familiar with complimentary techniques such as HDX-MS, and cryo-electron microscopy. Experience with antigen and antibody design software (MOE, Rosetta, Yasara). Be a self-starter able to handle multiple projects concurrently. Good knowledge and understanding of GSK Vaccines strategy and objectives, regulatory, requirements, as well as competition intelligence and intellectual property aspects. Ability to integrate this knowledge in decisions and recommendations. Excellent communication skills, ability to effectively collaborate within multiple project workstreams. Strong track-record of scientific publications in peer-reviewed journals, with at least 1 first author research manuscript. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness *This is a job description to aide in the job posting, but does not include all job evaluation details. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

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