A postdoctoral position is available for recent graduates to study the mechanisms of human retinal development and disease. Pluripotent stem cell technology offers amazing new opportunities to study human eye development and disease. In particular, 3D retinal organoids can recapitulate many aspects of the human eye including the cellular and molecular composition of the eye, thus offering an attractive humanized model for experimental studies. Among the current projects, our lab studies three main area of research. First, we study human retinal development using 3D retinal organoids with built in CRISPR- edited reporters. Gene-editing is also used to explore retinal mechanisms of retinal development by gain- and loss-of-function. Second, we study human retinal degeneration including Leber congenital amaurosis (LCA), macular degeneration, and glaucoma using genetically engineered stem cells with patient specific mutations. Lastly, our lab is exploring new ways to reverse degeneration by exploiting a process of endogenous repair. This later approach is analogous to a lizard growing a new tail except our system is the eye.
This position will utilize human pluripotent stem cells to model retinal eye development and disease and will rely on cell-type specific stem cell-based reporters. These projects will also entail gene knock-out or down to phenocopy developmentally relevant or disease associated alleles. We seek a postdoctoral fellow to combine cell biology and human genetics to study one of the areas outlined above. Candidates should be highly motivated with a Ph.D. degree in the biomedical sciences and a strong background in biochemistry and cell biology. While experience in human stem cell differentiation and bioinformatic analysis by RNAseq or scRNAseq is highly desirable but not required. Important qualities will be intellectual curiosity and a positive growth mindset. Postdoctoral candidates will receive training in gene-editing, stem cell biology, bioinformatics and will learn to interact with basic scientists and clinicians in a multidisciplinary environment. For details of the research projects, please visit: http://wahlinlab.ucsd.edu
Please email CV and the names and contact info of three references to:
Karl Wahlin, Ph.D.