Sr Associate Scientist, Biologics Discovery
Sr Associate Scientist, Biologics Discovery
United States - California - Foster City
Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gileads therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.
Making an impact on a global scale
Inclusion is one of the companys five core values. Thats because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.
When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible
Gilead is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world.
The Biologics Discovery group is a specialized team within the Protein Therapeutics function that is responsible for the discovery and optimization of biologic drug candidates. We seek a highly motivated Senior Associate Scientist to join this team in a newly created position. The successful candidate will use single B-cell technologies to enable antibody discovery in support of all therapeutic areas at Gilead. The candidate will also work on cross-functional teams and be a part of a functional area specializing in the discovery and screening of novel biologic modalities across several therapeutic areas.
Essential Duties and Job Functions:
In this laboratory-based role, the successful candidate will support efforts to generate novel antibody-based therapeutics through single B-cell technologies. They should have knowledge of antibody structure and function with experience in antibody discovery technologies, molecular biology, cell culture, and basic characterization assays. Additional job requirements:
- Work cross-functionally and across therapeutic areas to carry out rodent B-cell isolation, antibody molecular cloning and reformatting, and initial characterization
- Interact and collaborate with Protein Therapeutics and Data Science colleagues to support NGS-based antibody discovery and optimization efforts
- Independently design, analyze and interpret experiments to characterize the binding and functional properties of novel antibodies
- Deliver scientific presentations in lab and project team meetings
- Maintain familiarity with relevant scientific literature
Knowledge, Experience and Skills:
M.S./B.S. in biological sciences, preferably with at least 14 years of relevant professional experience and a proven track record of successful antibody discovery. Job title is flexible based on experience. An ideal candidate will have experience in most of the following areas:
- Hands-on experience in antibody discovery and development methods
- Experience with molecular biology and cloning
- Experience with biochemical assays and quantitative analysis of protein-protein binding interactions (e.g. FACS, ELISA, Octet, etc.)
- Experience with single-cell FACS sorting highly desired
- Mammalian cell culture and transient protein expression experience is a plus
- Knowledge of antibody structure/function relationships is a plus
- Prior experience with antibody sequence analysis from discovery campaigns is a plus
- Experience with high-throughput liquid handling systems is a plus (e.g. Biomek, Hamilton, etc.)
- Laboratory animal handling and immunization experience is a plus
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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact firstname.lastname@example.org for assistance.
Following extensive monitoring, research, consideration of business implications and advice from internal and external experts, Gilead has made the decision to require all U.S. employees and contractors to receive the COVID-19 vaccines as a condition of employment. Full vaccination is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.
For more information about equal employment opportunity protections, please view the EEO is the Law' poster.
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