Principal Investigator

Singapore (SG)
Competitive salary and attractive benefit package will be offered
August 20 2021
Position Type
Organization Type

The Genome Institute of Singapore (GIS) is the national flagship program for genomic sciences in Singapore. The Agency for Science, Technology and Research (A*STAR) is the parent funding body for the GIS and has a long-term commitment to create a world-class infrastructure. As one of the premier genomic centers, the GIS integrates genetics, genomics and cell biology to gain fundamental, translational and clinical insights into human diseases and health ( 

The GIS invites applications for outstanding Principal Investigators at the mid-career or senior level. We are seeking highly motivated individuals to develop their independent research programs in the following domains:

Precision Medicine and Population Genomics (Germline): Elucidating the role of human genes in the pathology of human diseases, leading to the long-term goal of translating genomic findings into predictive medicine to improve Singapore healthcare. Candidates should have a relevant PhD / postdoctoral training in one of the following areas; genetic association studies, statistical genetics, genetic epidemiology, a previous track record in the isolation of disease genes, and/or functional genomics.

Precision Medicine and Population Genomics (Somatic): Application of functional genomics, clinical genomics, and computational biology approaches to understand the origins, evolution, and progression of cancer. Collaborating with oncologists, we employ genomics and multi-omics technologies to understand cancer predisposition, and to map the course of disease progression in the clinical setting for informing the clinical decision-making process to improve treatment outcomes. Leveraging on functional genomic tools, we seek to interrogate the function of disease-causing genes to enable target discovery that can fuel the design of novel treatment modalities to inhibit disease progression. Areas of interest include, but are not limited to, cancer genomics, cancer vaccines, cancer microbiome, cancer immunology, and artificial intelligence models of cancer.

Spatial and Single Cell Systems: Development of cutting-edge, high-resolution, multi-analyte omics technologies, algorithms and platforms to transform cell and tissue biology, disrupt omics research and pathology markets, and drive clinical translation. We are looking for a new faculty who can synergize with existing programs in cancer, neuroscience and other areas to drive spatial and single cell technology development, early adoption, clinical applications and commercialization. This call is open to technologists as well as cell, organismal and computational biologists. Our recruits will benefit from unique spatial and single cell platforms, a vibrant and open-minded atmosphere, colleagues with deep domain expertise, and a network of local and international collaborators, scientific consortia and industry partners.

Epigenetic and Epitranscriptomic Regulation: Development of new technologies to understand the functions of epigenetics and epitranscriptomics in human health. In close collaboration with other domains, we aim to understand the roles of DNA and RNA modifications in a genome-scale level across different human populations and diseases, with the final goal of being able to target these modifications for disease treatment. We are looking for highly motivated individuals to develop their independent research program. These include early career independent fellows, as well as PIs at the mid-career or senior level.

Genome Architecture: Develop new technologies to analyze genome structure and function for non-model organisms, including bacteria, fungi, plants and animals. We are looking for scientific leaders in the development of computational and experimental technologies for de novo genome assembly, genome structure analysis and metagenomics, as well as domain experts in large-scale bacterial, fungal and plant genomics for medical, biodiversity and biotechnology applications. Candidates with established track records in microbiome studies, fungal genomics, high-throughput microbial genomic assays, and plant genome biology are highly desirable.

Genome Design: Build technologies to engineer DNA or RNA (including viral/non-viral delivery, gene therapy, modified DNA/RNA, CRISPR-Cas, DNAzymes/ribozymes, and other editing systems). Candidates with established track record in nucleic acid therapeutics development, genomics technologies development, translation into clinical trials, and/or biotech companies are highly desirable.

Qualified candidates should have a PhD in the biological, genomic or computational sciences, and a demonstrated ability to conduct cutting-edge research with a strong record of peer-reviewed publications, intellectual property creation, and external funding. You must be comfortable working in a dynamic research organization and be able to balance multiple responsibilities. Strong communication skills and a willingness to work collaboratively in a multidisciplinary environment are critical for success. The successful candidate will drive an expansion into the indicated research areas and complement and synergize with ongoing research programs at the GIS.   

Applicants should submit a CV, a statement of research interests and the names of four references by email to this link.

Genome Institute of Singapore

60 Biopolis Street

#02-01 Genome

Singapore 138672



The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice.

* We regret that only shortlisted candidates will be notified.

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