Postdoctoral Research Scientist in Peripheral Nerve development, myelination and Cancer

Postdoc positions are immediately available for NIH funded project(s) to study Peripheral nerve myelination, tumorigenesis or repair to extend the recent findings of Son laboratory.

(1) TEAD1 predominantly mediate YAP/TAZ to develop and repair Schwann cell myelination. Grove M...Son YJ (in preparation)

(2) Synapsing with Oligodendrocyte progenitors prevent regeneration of sensory axons into the spinal cord. Kim H...Son YJ (in preparation)

(3) Co-targeting BRAF and PTEN in IB4+ neurons promote regeneration of broad sensory neurons into the spinal cord. Kim H, Noristiani H...Son YJ (in preparation)

(4) Co-targeting myelin inhibitors and CSPGs markedly enhances regeneration of GDNF-stimulated, but not conditioning-lesioned, sensory axons into the spinal cord.  Zhai J...Son YJ, eLIFE 2021 DOI: 10.7554/eLife.63050

(5) Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury. Grove M...Son YJ, Elife. 2020 doi: 10.7554/eLife.50138.

(6) YAP/TAZ initiate and maintain Schwann cell myelination. Grove M...Son YJ, Elife. 2017 doi: 10.7554/eLife.20982.

Ph.D. degree in Neuroscience, Biochemistry, Cancer biology or related field is required. We use mouse models of peripheral nerve or spinal cord injury and apply microsurgery, widefield and multiphoton in vivo imaging, conditional/inducible transgenic mice, in vivo AAV or lenti viral transduction, neuronal and glial cell cultures, electrophysiology, TEM/SEM, confocal microscopy, behavioral analysis of motor and sensory functions, IP, Chip-seq, proteomics or RNAseq profiling. Applicants competent with at least some of these techniques and have a prior research experience with intracellular signaling pathways, axon regeneration, Hippo signaling, Schwann cells, myelination, viral gene therapy or Schwannoma cancer biology is preferred.

Our Center is focused on spinal cord and peripheral nerve regeneration offering excellent training opportunity for students in the field. Salary will follow NIH scale with excellent benefit package.

https://medicine.temple.edu/departments-centers/research-centers/shriners-hospitals-pediatric-research-center/faculty

Please email a cover letter (briefly mentioning your previous experience), CV and names of three referees, to Dr. Son.

Young-Jin Son, PhD

Professor of Dept. Neural Sciences

Shriners Hospitals Pediatric Research Center

Lewis Katz School of Medicine, Temple University

3500 N Broad St.

Philadelphia, PA 19140

yson@temple.edu

Shriners Hospitals Pediatric Research Center is a collaboration between Shriners Hospitals for Children® and Temple University School of Medicine.  Temple University is an EEO/AA employer and strongly encourages applications from women and minorities.