Research Associate II - Super-Resolution Microscopy

Location
Duarte, California
Salary
Competitive
Posted
August 05 2021
Ref
10012738
Discipline
Life Sciences
Position Type
Full Time
Organization Type
Healthcare/Hospital
Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions.

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

A Research Associate II (RAII) position is available in the laboratory of Dr. Tijana Jovanovic-Talisman . Biological nanoparticles that are continuously shed by cells - namely extracellular vesicles (EVs) - are an emerging and exciting strategy for performing minimally invasive diagnos es . Because EVs are loaded with disease specific molecules, they represent an excellent source of biomarker s . The project will apply super-resolution microscopy methods to characterize EVs and their content. Specifically, super-resolution imaging will be used to characterize EVs from heart, brain, and immune cells. The approach will be also used to quantify a subpopulation of EVs associated with disease. Ultimately, the goal is to perform molecular level diagnoses for precision medicine.

Under general supervision of the Principal Investigator, or designee, the Research Associate II (RAII) directs the work of a laboratory or undertakes research projects in collaboration with academic supervisor, making innovative contributions pertaining to laboratory procedures which may not change the course of an investigation but do indicate significant independent contribution beyond the RA I level. RAII typically consults with the academic supervisor on the scope and plan of approach to a research project; reads abstracts and articles; organize and plan techniques; plan and assign the work of at least one lab staff advising on problems they are unable to solve; contribute original ideas to the laboratory research; standardize new techniques and train staff on these techniques; perform specialized procedures and prepare written reports of laboratory experimental methods.

Key Responsibilities include:
  • The RAII will culture cells, purify EVs from cultured cells and plasma, fluorescently label EVs, and characterize EVs using nanoparticle tracking analysis, western blots, and super-resolution microscopy.
  • Performs a variety of routine and non-routine laboratory research experiments. Records and validates results for accuracy and completeness.
  • Troubleshoots procedures if experiment results are unexpected or unsatisfactory. Recommends alternative procedures.
  • Responsible for accurately recording work performed including results and methodology. Calculates, compiles, and analyzes data obtained from work performed.
  • Independently evaluates research data and initiates alternative approaches to improve the quality of results by providing input to overall research design. Trains lab staff in specialized procedures, equipment, and theoretical concepts behind unique tests.
  • May contribute to the preparation of manuscripts by describing methods and specialized techniques. Keeps abreast of new and improved techniques.
  • Ensures that all laboratory activities are carried out in compliance with each procedure(s) by utilizing safety procedures and guidelines in handling, storage and disposal of bio-hazardous, infectious and toxic material.


Basic education, experience and skills required for consideration:
  • Bachelor's degree in biomedical sciences, cell, biology, or a related discipline is required.
  • Two years related research/ laboratory experience with a Bachelor's degree or one year related research/ laboratory experience with a Master's degree.
  • Experience in microscopy and cell biology
  • Excellent computer skills


Preferred education, experience, and skills:
  • Master's degree
  • Extracellular vesicle experience is preferred.


Additional Information:
  • For more information on the Jovanovic-Talisman Lab, please click here .
  • To apply, please send your CV/resume to Dr. Talisman at ttalisman@coh.org .
  • To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.


City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

  • Posting Date: Aug 4, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job

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