Senior Associate Scientist, Protein Purification (non PhD)

Cambridge, Massachusetts
August 04 2021
Position Type
Full Time
Organization Type

Pfizer's BioMedicine Design Biotherapeutic Expression and Purification group (BEP) is seeking a candidate to join their team. The candidate will play an essential role in a high-energy protein purification research laboratory. The purification group is responsible for non-GMP protein drug lead generation, supporting the various Pfizer research units and their pre-clinical therapeutic in-vitro and in-vivo needs. The candidate will be responsible for processing of mammalian- expressed recombinant protein modalities including, but not limited to, monoclonal antibodies, bispecific antibodies, Fc-fusions, his tag proteins through the use of state-of-the-art technologies and equipment. The candidate will contribute to the group wide deliverables and be required to work on several projects simultaneously presenting results and updates at group meetings.

  • Develop efficient purification protocols for novel biotherapeutic candidates
  • Provide highly-purified biotherapeutic candidates to discovery project teams
  • Drive technology innovation; design, suggest and/or implement strategies to increase throughput and/or efficiency
  • Work closely with peers to meet deadlines and project goals
  • Effectively troubleshoot technical issues
  • Independently perform experiments using a wide-range of chromatographic, analytical techniques and bioconjugation reactions
  • Maintain high quality lab notebook and demonstrate effective record-keeping
  • Present reports to the BEP group and project teams
  • Experience in working with proteins and antibodies
  • Experience with bispecific antibodies
  • Experience in bioconjugation techniques
  • Knowledge of chemical reactions
  • Conjugation and purification of multiple conjugated products
  • Ability to multitask
  • Knowledgable and experienced in preparative and analytical IEX, SEC, HIC, and other chromatography methods
  • mass spectrometry, ELISA, SDS-PAGE gel, endotoxin assay

  • B.S./MS in Biochemistry, Biology, Biomedical Sciences or a related discipline with 1-3 years of relevant experience along with an understanding of biotherapeutic production
  • Understanding of proteins and protein purification as well as conjugation chemistries
  • Experience or knowledge in the operation of AKTA (LC) and Agilent (HPLC) chromatography systems
  • Strong communication skills, written and oral

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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