Institute Principal Research Scientist - Medicinal Chemistry

Location
Houston, Texas
Salary
Competitive
Posted
August 02 2021
Ref
142224
Discipline
Health Sciences
Organization Type
Healthcare/Hospital
The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public.

MD Anderson is known for providing cancer patients with exceptional care, which includes early access to innovative new treatments through clinical trials. The Institute for Applied Cancer Science (IACS) is a new hybrid model that uniquely combines the drug discovery capabilities of the biopharmaceutical industry and the extensive knowledge of biology found in academia with the expertise of MD Anderson's top clinicians. IACS has the singular goal of rapidly developing novel, effective and safe therapeutics that improve patient health. IACS executes programs with the highest probability of clinical success in a rigorous, goal-oriented, data-driven manner.
The Institute Principal Scientist, Medicinal Chemistry, will responsible for the leadership and execution of the Medicinal Chemistry strategy of small molecule oncology drug discovery programs. By liaising with other members of the cross functional project team drug discovery teams, including computational chemistry, in vitro pharmacology and biology teams, this individual will be playing a key role in the identification and optimization of the next generation of cancer therapeutics.

KEY FUNCTIONS

1. Lead the planning and execution of the medicinal chemistry strategy for a drug discovery program.
2. Plan and execution the medicinal chemistry optimization of one or more chemical series to improve potency, selectivity, efficacy, tolerability and ADME profile, resulting in the nomination of clinical candidates suitable for development.
3. Enable advancement of IACS projects through leadership and experimental activities.
4. Work closely and liaise with other functional areas for study and execution of experimental studies to enable advancement of IACS drug discovery programs.
5. Analyze data generated by various studies and leverage results for the design of future studies.
6. Adapt new synthetic and computational chemistry approaches and technologies to find solutions to issues, and to improve the overall performance of the Med Chem team.
7. Contribute patent filing in order secure the intellectual property rights for novel small molecules.
8. Resource projects in a flexible manner, including the efficient use of outsourcing.
9. Supervise and develop medicinal chemistry staff.
10. Enable advancement of IACS projects through leadership and experimental activities.
11. Employ safe lab practices.
12. Maintain research records and laboratory notes.

Education

Required: PhD in one of the natural sciences or related field or Medical degree.

Preferred: PhD in synthetic organic chemistry or medicinal chemistry.

Experience

Required: Five years experience of relevant research experience in lab.

Preferred: Relevant industrial experience within the pharmaceutical or biotech industry, with track record of previous contribution to at least one successful medicinal chemistry discovery, optimization and development project.

The ideal candidate will have strong synthetic organic and medicinal chemistry background, a broad understanding of the drug discovery process and of the requirements to successfully develop new clinical agents. He/She will have demonstrated ability to design small molecules to optimize multiple physical/pharmacological parameters simultaneously, a strong knowledge of medicinal chemistry and contemporary synthetic organic chemistry, with a demonstrated track record of creative independent problem solving. Experienced at contributing to medicinal chemistry teams, solving problems to advance projects toward the clinic and be well versed in harnessing the potential of computational chemistry methods to position programs towards success. Experienced in mentoring medicinal chemistry team members. Strong publication record in peer reviewed journals. Excellent communication, writing, and organizational skills are a must. Ideally, the candidate will be familiar with oncology drug discovery and have some understanding of cancer biology.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

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