Investigator, Chemistry (Encoded Library Technologies)
Site Name: USA - Massachusetts - Cambridge Posted Date: Jul 13 2021 GlaxoSmithKline is a science-led global healthcare company that researches and develops a broad range of innovative products in the areas of Pharmaceuticals, Vaccines and Consumer Healthcare. By drawing upon the in-depth expertise of teams of multi-disciplinary scientists, we discover and develop novel medicines that will help patients do more, feel better and live longer. We are currently seeking an organic chemist to join the Encoded Library Technologies (ELT) group. The successful individual will serve as a key technical resource to support ELT hit follow-up efforts, on-DNA reaction development and DNA-Encoded Library (DEL) design and synthesis. By working with other group members, and collaborating closely with colleagues across GSK, the successful individual will develop and optimize efficient, user-friendly next-generation chemical technologies and embed them in library synthesis workflows. Key Responsibilities: ELT selection data analysis, hit triaging, chemistry planning and communication of results Independently plan and implement efficient synthetic routes to molecules of interest, applying state of the art purification and characterization techniques for hit confirmation and, when applicable, parallel synthesis hit to lead SAR generation necessary to progress chemical series through the discovery pipeline Develop new synthetic methods (both traditional and DNA compatible methods) as needed, and help identify and implement innovative technologies Independently author peer review scientific papers, internal/external presentations and technical reports, represent GlaxoSmithKline at external scientific meetings, and present research internally to stakeholders and management Maintain accurate records as required by GlaxoSmithKline policies and ensure that GSK Intellectual Property is protected Share in responsibilities to support general lab functions Contribute to writing and conceptual framework of publications, presentations and patents Establish and maintain a detailed knowledge of literature related to areas of research Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: PhD in Organic Chemistry, Synthetic Methodology Development, Synthetic Organic Chemistry or Medicinal Chemistry Experience in synthetic chemistry; knowledgeable in the application of new synthetic methodology Preferred Qualifications: If you have the following characteristics, it would be a plus: Strong understanding of structure activity relationships and ability to design target molecules with robust rationale Experienced in use of cheminformatics and other computational tools in drug design Strong record of peer reviewed publications, patents or presentations Familiarity of on-DNA synthesis, on-DNA reaction analysis and encoded library synthesis methods Working knowledge of contemporary parallel synthesis and /or high-throughput experimentation technologies An understanding of contemporary synthetic methodologies (catalysis, biocatalysis, C-H activation / functionalization) in the context library-based synthesis applications An ability to work with other scientific disciplines to drive results Demonstrated ability to critically review and effectively communicate scientific data and to influence outside of core area of expertise Self-motivated with an ability to work effectively in a collaborative, multidisciplinary matrix environment Highly organized with strong attention to detail and a focus on quality results Excellent oral and written communication skills Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness For further information see the following references: Clark et al. Design, Synthesis and Selection of DNA-Encoded Small-Molecule Libraries. Nat. Chem. Biol. 2009, 5, 647-654. Arico-Muendel. From haystack to needle: finding value with DNA encoded library technology at GSK. MedChemComm 2016, 7, 1898-1909. DOI:10.1039/c6md00341A Machutta & Kollmann et al. Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening. Nat. Commun. 2017, 8, 16081. DOI:10.1038/ncomms16081 Phelan et al. Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis. J. Am. Chem. Soc. 2019, 141, 8, 3723-3732. DOI: 10.1021/jacs.9b00669 *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. 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