Principal Scientist- Immunoassay

Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Principal Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will have the important role to generate high-quality immunoassay data in a regulated cGLP laboratory setting to support Pfizer's vaccine programs according to Standard Operating Procedures. You will support the technology transfer of assays, manage clinical sample testing and associated assays, and oversee clinical testing-associated functions at external Clinical Research Organizations (CRO).

In addition, you will work with the leadership to plan, design and critically analyze experiments to support the development and qualification/validation of assays at CROs as well as monitor assay performance and actively lead efforts in assay investigations. You will also identify new opportunities for collaboration and outsourcing of Pfizer clinical sample testing needs. Your skills and expertise will ensure that all work is managed in a compliant manner according to relevant Standard Operating Procedures and cGLP (current Good Laboratory Practice) and/or cGMP (current Good Manufacturing Practices).

You will be recognized as a technical expert and a significant scientific contributor. With your deep knowledge of the discipline, you will regularly contribute at the therapeutic area level and can represent the department on multidisciplinary teams. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will undertake mentoring activities to guide team members.

It is your hard work and commitment that will make Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

• Regularly contribute at the therapeutic area level and represent the group on multidisciplinary teams.
  
• Influence at the therapeutic area/discipline level and increasingly at the project team level.
  
• Design research studies as part of fit for purpose vivo immuno-oncology-related models for identifying and profiling the immunologic effects of our immunotherapeutic platforms.
  
• Work closely with individuals in both protein engineering and immunology/oncology groups to innovate and develop the next-generation protein therapeutics for cancer immunotherapy.
  
• Work with project teams to define study aims and experimental plans that meet the objectives of the research plan.
  
• Responsible to drive overall strategy for the projects, which include both internal and in-licensed projects.
  
• Work with key stakeholders across commercial, clinical and Pfizer Global Supplies to define the product concept and lead the operational planning for assigned projects.
  
• Prove a single point of accountability for assigned projects, interacting as necessary with stakeholders at all levels of management to convey project information and manage expectations.
  
• Lead technology transfer of immunoassays, including manual and automated methods, and integration of various laboratory processes into the cGLP laboratory space to maintain efficient high throughput testing and to achieve high-quality results.
  
• Provide clear, concise and timely responses to project team requests for experimental information, and guide and develop laboratory-based scientists.
  
• Conduct research that leads to publication in peer-reviewed journals and presentation of data at internal and external meetings and conferences.
  
• Satisfactorily complete all cGLP training and safety training in conformance with departmental requirements.
  

Qualifications

Must-Have

• Bachelor's Degree
  
• 12+ years of experience
  
• Expertise in protein chromatography, protein concentration and formulation, and cutting-edge protein analytical techniques will be key to this position
  
• Demonstrated abilities with molecular biology, biochemistry and imaging techniques to study vector transduction in vitro and in vivo
  
• Hands-on skills in protein expression, purification and characterization using biochemical/biophysical and functional assays
  
• Breadth of knowledge of different areas of science, awareness of new technologies, and familiarity with current issues to apply novel and innovative approaches to problem solving
  
• Excellent verbal and written communication skills
  
• Proficiency in the use of Word processing, Excel, PowerPoint and relevant scientific software
  

Nice-to-Have

• PhD with 4+ years of relevant experience
  
• Experience characterizing and developing therapeutic drugs, including antibodies and fusion proteins
  
• Managerial experience, preferably in a commercial research and development setting
  
• Knowledge of protein structural biology
  

PHYSICAL/MENTAL REQUIREMENTS

Complex data analysis

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

May require travel and/or nonstandard work hours to achieve departmental goals

Other Job Details

Eligible for Relocation Package

Eligible for Employee Referral Bonus

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Research and Development