Pfizer

Senior Scientist, Immunosuppression

Employer
Pfizer
Location
La Jolla, California
Salary
Competitive
Posted
July 30 2021
Ref
4819751
Position Type
Full Time
Organization Type
Pharma
Job Type
Senior Scientist
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

ROLE SUMMARY

Pfizer Cancer Immunology Discovery (CID) is within the Oncology division of Pfizer Worldwide Research & Development in La Jolla, CA. CID is dedicated to developing new small molecule and protein therapeutics to improve human life by redirecting the immune system against cancer. CID researchers apply the latest scientific knowledge and novel approaches to discover truly innovative Immuno-Oncology therapeutics. We are seeking to hire Senior Scientist for the CID Immunosuppression group.

ROLE RESPONSIBILITIES
  • Discovery and evaluation of novel mechanisms of immunosuppression in the tumor microenvironment
  • Design and execution of cell based functional and biochemical assays to perform target validation and select candidate molecules for clinical development
  • Design and execution of drug mechanism of action studies using in vivo models and ex vivo methods, such as cell sorting, multi-color flow cytometry, i mmunohistochemistry/immunofluorescence, and primary cell culture and human 3D/organoid/explant assays.
  • Communication of research results to the team and leadership


BASIC REQUIREMENTS
  • Ph.D. with postdoctoral research experience
  • Experience in the fields of immunology, oncology, cell biology and/or genetics
  • Ability to independently design, plan and execute and interpret experiments
  • Ability to manage an independent research program with minimal supervision
  • Experience working with biologics and/or small molecules inhibitors for tumor immunotherapy
  • Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, proliferation, and suppression assays by using monocyte/ macrophages, T-cells, or dendritic cells, tumor-stroma immune cell co-culture assays).
  • Experience in CRISPR technology, lentiviral transduction, data mining (TCGA, single cell RNA sequencing, cBioportal) is a plus.
  • Expertise in 3D spheroids and complex ex vivo assays that mimic human tumor microenvironment.
  • Experience with human PBMCs and mammalian cell culture
  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic


PREFERRED QUALIFICATIONS
  • Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, proliferation, and suppression assays by using monocyte/ macrophages, T-cells, or dendritic cells, tumor-stroma immune cell co-culture assays).
  • Expertise in 3D spheroid and other complex ex vivo assays that mimic human tumor microenvironment.
  • Experience with human PBMC and mammalian cell culture
  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic


Other Job Details

Eligible for Relocation Package

Eligible for Employee Referral Bonus

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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