Sr. Scientist - Biochemical and Quantitative Pharmacology

La Jolla, California
July 30 2021
Position Type
Full Time
Organization Type
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring best-in-class medicines to patients around the world.

Role Summary

Pfizer Oncology Research & Development (ORD) is seeking a Senior Scientist (PhD level) to join our Biochemistry and Quantitative Pharmacology (BQP) group. The candidate will join our interdisciplinary and highly collaborative team to support and advance our preclinical oncology drug pipeline. The ideal candidate will have a strong background in cellular and molecular biology, in vitro pharmacology, and biochemical and cellular assay development. Special consideration will be given to candidates that have expertise in immuno-oncology and/or cell cycle biology. The successful candidate will have a proven track record of scientific success as evidenced by publications in peer-reviewed journals. This position will provide the motivated candidate with ample opportunity for scientific growth through exposure to all aspects of the drug discovery process.

Role responsibilities
  • Develop and validate relevant assay systems to screen and characterize small molecules in medium and high-throughput formats.
  • Design, execute, analyze, and clearly communicate experimental results to drive SAR and explore novel drug targets.
  • Serve as BQP representative on project teams as key contributor responsible for reading current biological and technical literature and contributing new ideas to advance project work.
  • Contribute to a culture that prioritizes scientific discovery, pursues excellence, and encourages growth.

Basic Qualifications
  • PhD in the biological sciences with 2-5 years of relevant postdoctoral experience.
  • Demonstrated success in small molecule drug discovery with expertise in oncogenic signaling mechanisms and cellular pharmacology.
  • Broad knowledge of high throughput biochemical and cellular assay development including functional assays, binding assays, PPI, proliferation, degradation, and reporter assays (such as TR-FRET, NanoBRET, thermal shift, CETSA, Alpha-Screen, HiBit, flow cytometry, Mesoscale/ELISA, etc.).
  • Experience designing complex experiments to identify compound mechanism of action.
  • Attention to detail and ability to prioritize project timelines and daily activities.
  • Effective oral and written communication skills.
  • Fluency in basic data analysis software such as GraphPad, Excel, Activity Base, etc.

Preferred Qualifications
  • Extensive knowledge and understanding of cancer mechanisms including but not limited to immuno-oncology, DNA damage/repair, oncogenic driver signaling, epigenetics, therapeutic resistance, and apoptosis. Preference for candidates with expertise in cancer cell cycle regulation or immuno-oncology.
  • Experience in the design and execution of high-throughput small molecule, phenotypic, or genetic screens, including automation and large dataset analysis.
  • High Content screening experience is a plus.

Other Job Details
  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus


Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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