Postdoctoral Fellow in RNA Biology
Multiple postdoctoral researcher positions are available for NIH-funded research in the lab of Dr. Yohei Kirino at Computational Medicine Center (CMC)/Department of Biochemistry and Molecular Biology in Thomas Jefferson University (TJU). Overall research goal of the Kirino lab is to understand the biogenesis mechanism and molecular function of short non-coding RNAs (ncRNAs) and use the knowledge for development of novel biomarkers and therapeutic applications in diseases. By taking advantage of RNA biology/biochemistry, molecular/cellular biology, and computational biology, the Kirino lab is particularly focused on transfer RNA (tRNA)-derived ncRNAs, cyclic phosphate-containing RNAs (cP-RNAs), and Piwi-interacting RNAs (piRNAs), which play crucial roles in various biological processes and diseases (https://research.jefferson.edu/labs/researcher/kirino-laboratory.html).
Highly-motivated individuals with strong background in RNA biology and/or molecular/cell biology are awaited. Experience on bioinformatics analysis or animal research is advantageous but not essential. Applicants should have a Ph.D. degree, a productive track record, and a high writing and communication skills. The successful applicant will have a unique opportunity to work in close collaboration within CMC, the Department, and with other research groups in TJU, UPENN, and other institutions.
Applicants should send 1) a cover letter with a description of past research experience and future research/career goals, 2) CV, and 3) contact information of 3 references to Dr. Yohei Kirino at Yohei.Kirino@jefferson.edu.
Yohei Kirino, Ph.D.
Computational Medicine Center
Department of Biochemistry and Molecular Biology
Sidney Kimmel Medical College
Thomas Jefferson University
1020 Locust Street, Jefferson Alumni Hall 222
Philadelphia, PA 19107
Selected recent publications:
Shigematsu, M., et al. “RNase κ promotes robust piRNA production by generating 2',3'-cyclic phosphate-containing precursors.” Nature Communications, 12 (1): 4498, 2021. [Pubmed]
Pawar, K., et al. “Infection-induced 5'-half molecules of tRNAHisGUG activate Toll-like receptor 7.” PLoS Biology, 18 (12): e3000982, 2020. [Pubmed]
Shigematsu, M., et al. “Genome-wide identification of short 2',3'-cyclic phosphate-containing RNAs and their regulation in aging.” PLoS Genetics, 15 (11): e1008469, 2019. [Pubmed]
Honda, S., et al. “The biogenesis pathway of tRNA-derived piRNAs in Bombyx germ cells.” Nucleic Acids Research, 45: 9108-9120, 2017. [Pubmed]
Shigematsu, M., et al. “YAMAT-seq: an efficient method for high-throughput sequencing of mature tRNAs.” Nucleic Acids Research, 45: e70, 2017. [Pubmed]
Honda, S., et al. “Selective amplification and sequencing of cyclic phosphate-containing RNAs by the cP-RNA-seq method.” Nature Protocols, 11: 476-489, 2016. [Pubmed]
Honda, S., et al. “Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers.” Proceedings of the National Academy of Sciences, USA, 112: E3816-E3825, 2015. (Featured in “In This Issue”) [Pubmed]
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