Pfizer

Associate Scientist, Biochemistry

Employer
Pfizer
Location
Groton, Connecticut
Salary
Competitive
Posted
July 28 2021
Ref
4820066
Position Type
Full Time
Organization Type
Pharma
ROLE SUMMARY

Pfizer currently has an open Associate Scientist position for a protein biochemist in the Structural and Molecular Sciences (SMS) department in Groton, CT. We are seeking a highly motivated individual with strong expertise in recombinant protein expression, purification and characterization and the desire to pursue challenging biomolecular targets for drug discovery. We are an integrated and highly collaborative team of colleagues with technical expertise in molecular biology, protein biochemistry, biophysics, and structural biology. We have a strong track record of enabling hit-to-lead progression for small molecule modulators of both soluble and integral membrane proteins using integrated biophysical and structural approaches. We actively collaborate with Pfizer drug discovery teams across multiple therapeutic areas including Immunology & Inflammation, Internal Medicine, Vaccines, and Rare Diseases, with a mission to advance drug and vaccine discovery efforts by providing comprehensive molecular and structural insights into therapeutic targets, lead molecules, and protein-ligand interactions.

ROLE RESPONSIBILITIES
  • Purify functional proteins or protein complexes for biochemistry, biophysics, and structure determination.
  • Characterize proteins by analytical and biophysical methods including western blot, aSEC, DLS, TSA to monitor stability, conformation, and oligomerization.
  • Apply various biophysical approaches (including SPR, ITC) to enable hit identification, validation, target engagement, and Mechanism-of-Action studies.
  • Be part of multi-disciplinary teams to support discovery projects across diverse disease areas.
  • Effective oral and written communication of experimental work and analysis.
  • Perform timely notebook entries and review for completed experiments.


QUALIFICATIONS
  • BS with 2-3 years of relevant laboratory experience required.
  • Proficient in the purification of recombinant proteins by affinity, IEX and SEC using FPLC (AKTA) systems.
  • Experience with the expression of recombinant proteins using bacterial and eukaryotic (insect, mammalian) expression systems.
  • Previous experience with biophysical assay formats and investigation of target-ligand interactions (ex: binding affinity) is a plus.
  • Ability to multi-task to balance parallel activities.
  • Ability to troubleshoot scientific and technical challenges and contribute to their resolution.


PHYSICAL/MENTAL REQUIREMENTS

Sitting, standing, lifting, bending, and walking. Ability to perform practical laboratory bench work and work on a computer (while standing or sitting). Ability to perform mathematical calculations and interpret data.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
  • Minimal, if any travel related to this position.
  • Candidate must comply with laboratory safety practices


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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