Associate Scientist, Biochemistry

Groton, Connecticut
July 28 2021
Position Type
Full Time
Organization Type

Pfizer currently has an open Associate Scientist position for a protein biochemist in the Structural and Molecular Sciences (SMS) department in Groton, CT. We are seeking a highly motivated individual with strong expertise in recombinant protein expression, purification and characterization and the desire to pursue challenging biomolecular targets for drug discovery. We are an integrated and highly collaborative team of colleagues with technical expertise in molecular biology, protein biochemistry, biophysics, and structural biology. We have a strong track record of enabling hit-to-lead progression for small molecule modulators of both soluble and integral membrane proteins using integrated biophysical and structural approaches. We actively collaborate with Pfizer drug discovery teams across multiple therapeutic areas including Immunology & Inflammation, Internal Medicine, Vaccines, and Rare Diseases, with a mission to advance drug and vaccine discovery efforts by providing comprehensive molecular and structural insights into therapeutic targets, lead molecules, and protein-ligand interactions.

  • Purify functional proteins or protein complexes for biochemistry, biophysics, and structure determination.
  • Characterize proteins by analytical and biophysical methods including western blot, aSEC, DLS, TSA to monitor stability, conformation, and oligomerization.
  • Apply various biophysical approaches (including SPR, ITC) to enable hit identification, validation, target engagement, and Mechanism-of-Action studies.
  • Be part of multi-disciplinary teams to support discovery projects across diverse disease areas.
  • Effective oral and written communication of experimental work and analysis.
  • Perform timely notebook entries and review for completed experiments.

  • BS with 2-3 years of relevant laboratory experience required.
  • Proficient in the purification of recombinant proteins by affinity, IEX and SEC using FPLC (AKTA) systems.
  • Experience with the expression of recombinant proteins using bacterial and eukaryotic (insect, mammalian) expression systems.
  • Previous experience with biophysical assay formats and investigation of target-ligand interactions (ex: binding affinity) is a plus.
  • Ability to multi-task to balance parallel activities.
  • Ability to troubleshoot scientific and technical challenges and contribute to their resolution.


Sitting, standing, lifting, bending, and walking. Ability to perform practical laboratory bench work and work on a computer (while standing or sitting). Ability to perform mathematical calculations and interpret data.

  • Minimal, if any travel related to this position.
  • Candidate must comply with laboratory safety practices

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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