Postdoctoral Scholar

Postdoctoral Position at the

Center for Craniofacial Molecular Biology, University of Southern California

Postdoctoral position is available immediately in Yang Chai's laboratory at the Center for Craniofacial Molecular Biology University of Southern California in Los Angeles, California. We are interested in the regulation of developmental patterning, organogenesis, stem cells and regenerative medicine. Our studies will seek to define molecular mechanisms governing both normal and abnormal craniofacial development, providing scientific rationales for future therapeutic strategies to prevent and treat craniofacial birth defects, as well as stem cell based craniofacial regenerative medicine.  The candidate must have a PhD and be experienced with molecular and developmental biology. Supported by the NIDCR, NIH, For details, please visit http://chailab.usc.edu/

Send application, resume and three letters of recommendation to

Yang Chai (c/o Ms. Linda Hattemer at Lhatteme@usc.edu).  EOE/AA

Our Recent publications:

1. Yu, M., Ma, L., Yuan, Y., Ye, X., Montagne, A., He, J., Ho, T. V., Wu, Y., Zhao, Z., Maria, N.S., Jacobs, R., Urata, M., Wang, H., Zlokovic, B.V., Chen, J., Chai, Y. (2021) Cranial suture regeneration mitigates skull and neurocognitive defects in craniosynostosis. Cell, 184, 243-256. PMID33417861.
2. Han, X., Feng, J., Guo, T., Loh, Y-H E., Yuan, Y., Ho, T-V., Cho, C., Li., J., Jing, J., Janeckova, E., He, J., Pei, F., Bi, J., Song, B., and Chai, Y. (2021) Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis. eLife, DOI: 10.7554/eLife.62387.
3. Du, J., Jing, J., Yuan, Y., Feng, J., Han, X., Chen, S., Li, X., Peng, W., Xu, J., Ho, T-V., Jiang, X., and Chai, Y. (2021) Arid1a-Plagl1-Hh signaling is indispensable for differentiation-associated cell cycle arrest of tooth root progenitors. Cell Reports, doi10.1016.
4. Yuan, Y., Loh, Y. E., Han, X., Feng, J., Ho. T. V., He, J., Jing, J., Groff, K., Wu, A., and Chai, Y. (2020) Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis. Science Advances, PMC7744069.
5. Chen, S., Jing, J., Yuan, Y., Feng, J., Han, X., Wen, Q., Ho, TV., Lee, C., and Chai, Y. (2020) Runx2+ niche cells maintain incisor mesenchymal tissue homeostasis through IGF signaling. Cell Reports, 32, 108007.
6. Zhao, H., Feng, J., Ho, T. V., Grimes, W. C., Urata, M., and Chai, Y. (2015) The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nature Cell Biology, 17, 386-396. PMCID: PMC4380556
7. Zhao, H., Feng, J., Seidel, K., Shi, S., Klein, O., Sharpe, P., and Chai, Y. (2014) Secretion of Shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell 14, 160-173. PMCID:PMC3951379