Senior Scientist, Cytometry Assays

Andover, Massachusetts
July 27 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist

We are seeking a highly motivated Senior Scientist to join the Cellular Bio-measures team in Pfizer's Bio-Medicine Design department. The position is integrated into a multi-disciplinary group responsible for the development, qualification and execution of cytometry assays in support of translational modeling for drug discovery programs across multiple therapeutic areas, including inflammation and immunology, cardiovascular, oncology and rare diseases. The successful candidate will apply their research experience, knowledge of biological systems and development of cell-based assays to independently plan and conduct quantitative analyses with a wide range of biotherapeutic modalities, implementing flow- and imaging flow- cytometry, and interpret and present experimental results to various multi-disciplinary teams. The Senior Scientist is expected to productively work as a team member in a fast-paced environment, managing several projects and contributing to team's deliverables.

  • Independent planning and execution of cytometry assays with biotherapeutic molecules, employing cellular systems from diverse tissue origins, and utilizing flow- and imaging flow- cytometry instruments to provide data on target cellular level, target-drug intracellular disposition, cell phenotype, cellular signaling and downstream functional response, enabling projects milestones and influencing portfolio decisions.
  • Development, adaptation and optimization of flow- and imaging flow- cytometry assays, applying "fit-for-purpose" rational to effectively balance assay rigor against resource needs and project goals.
  • Driving technology innovation, evaluation of new methodologies and instrumentation to advance implementation of cytometry-based bio-measures for project support.
  • Critical analysis of experimental data and communication of the results across multiple teams with diverse scientific and technical background.
  • Collaborative work with the members of the group; partnerships in a matrix environment; close communication with cross-functional teams to plan and execute deliverables and prioritize activities according to the project goals.
  • Adherence to scientific rigor and quality management system standards, including electronic record keeping, data peer-review, quality control and reporting.
  • Presentation of complex data internally at multi-disciplinary team meetings and externally at the scientific venues and through peer-reviewed publications.


  • M.Sc. (or equivalent) with >7 years, or Ph.D. (or equivalent) with >2 years of post-graduate research experience, ideally, some of which in pharmaceutical industry.
  • Demonstrated experience with light microscopy and quantitative cell imaging techniques for the analysis of cell phenotype, intracellular organelles, and functional read-outs.
  • Advanced knowledge of multi-parameter flow cytometry assays and high-dimensional cytometry data analysis.
  • Demonstrated expertise in developing and optimizing cell-based assays.
  • Excellent oral/written communication skills.
  • Demonstrated ability to interpret and then clearly and concisely communicate complex data.

  • Experience with imaging flow-cytometry (e.g., Amnis ImageStream).
  • Familiarity with CyTOF.
  • Experience with protein biochemistry techniques.
  • Demonstrated track record of independent research and scientific productivity, such as first-author publications in peer review journals.
  • Experience with record keeping using ELN.

  • As appropriate for this lab-based role.

  • Lab based position requirements to perform laboratory related activities and assist others in laboratory related activities.
  • Based in Andover.
  • Occasional travel to Cambridge (Kendal Square) might be needed, depending on project requirements.

Other Job Details:
  • Last Day to Apply: August 10, 2021
  • Eligible for Employee Referral Bonus
  • #LI-PFE

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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