Principal Scientist in Medicinal Chemistry and Molecular Design

La Jolla, California
July 25 2021
Position Type
Full Time
Organization Type
Principal Scientist in Oncology Medicinal Chemistry and Molecular Design

Pfizer, La Jolla, San Diego, CA

Would you like to discover the medicines of the future?

At Pfizer we deliver Breakthroughs That Change Patients Lives . In the Medicine Design group, we play a vital role in this mission through the discovery of Pfizer's small molecule drugs. We are seeking leaders in Medicinal Chemistry to join our world-class Medicine Design team in La Jolla, CA to build upon our rich history of innovation in Medicinal Chemistry, Molecular Design, and Structure-Based Drug Design to deliver Pfizer's drugs of the future.

Discovering new medicines at Pfizer requires teams that utilize a diverse set of skills, behaviors and approaches. Creativity, scientific excellence, tenacity, passion, hard work, organization, teamwork, courage, open-mindedness, curiosity - are just some of the traits successful Drug Discovery Scientists display at Pfizer. We are looking for ambitious Medicinal Chemists, eager to see their work lead to important new medicines and scientific breakthroughs, to join our team.

The Medicine Design group at Pfizer comprises experts in the major scientific disciplines involved in the discovery and preclinical development of small molecule drugs: molecular design, synthesis, computational chemistry, pharmacology, chemical biology, structural biology, biophysics, DMPK and analytical chemistry. We have long been renowned for delivering high quality drug candidates into the clinic and also for establishing new drug design approaches and principles, such as the "Rule of 5", LipE and property-based drug design, that have raised the bar of quality within the discipline and are widely-adopted across the industry.

As a Principal Scientist in Medicinal Chemistry and Molecular Design at Pfizer you will play a key role in large, multi-disciplinary matrix teams from project inception to delivery of clinical drug candidates. You will also contribute to teams of scientists that are combining Pfizer's expertise and large-scale research investments with external academic and biotech collaborations as a means to revolutionize our approach to the discovery and development of small molecule drugs

Role Responsibilities
  • Application of contemporary data analysis and design tools to drive effective target design and prioritization within a project
  • Effective use of both internal & external design resources available to the project team
  • Devise effective hit ID strategies to move projects through the Hit-to-Lead phase with scientific excellence, efficiency and speed
  • Play a key role in progressing projects through the Lead Optimization phase in partnership with enabling functions within Medicine Design to ensure the delivery of small molecule/synthetic drug candidates with scientific excellence, efficiency, and speed
  • Contribute to the identification of new small molecule projects by collaborating with oncology biologists
  • Play a role in enhancing the external reputation of Pfizer's Medicinal Chemistry, Molecular Design and synthetic Drug Discovery capabilities through publications and presentations at leading conferences
  • Work with local leadership to establish, maintain, and refine an active program of self-development in medicinal chemistry skills
  • Build effective collaborative working relationships with key partners in Synthesis, Chemical Biology, DMPK, Drug Safety, Protein Sciences, Biochemistry and Biology


Basic Qualifications
  • Doctorate level degree in organic chemistry, or equivalent industrial experience
  • Minimum 3 years of relevant experience in the Pharmaceutical Industry with examples of strong learning agility and problem solving
  • Good working knowledge of the key Medicinal Chemistry concepts and design tools required for pharmaceutical drug discovery
  • Examples of peer-reviewed publications from scientific work to date

  • Examples of impactful molecular design within a project team
  • Experience working in multi-disciplinary matrix teams to deliver project objectives with excellent teamwork skills

Other Job Details
  • Last Date to Apply for Job: July 30, 2021
  • Eligible for Relocation Package - Yes

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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