Senior Scientist, Pharmacology

Boulder, Colorado
July 25 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist
Role Summary

We seek an accomplished Senior Scientist level immuno-oncologist or oncologist to join the Pharmacology group within Pfizer Boulder Research (PBR), Boulder, Colorado. The successful candidate will join a dynamic team of scientists in the Pharmacology and Toxicology Group, playing a lead role in using models of cancer to evaluate new drug candidates, mechanisms, and targets.

The Senior Scientist will participate in exploratory in vivo biology, pre-clinical drug discovery/development programs, and translational studies with a focus on both immuno-oncology and tumor intrinsic biology. The candidate will contribute to the identification and characterization of new targets/therapeutic modalities and to the development of small molecule drugs in pipeline programs in close collaboration with partner lines. The ideal applicant will develop cutting edge in vivo mouse and human cancer models. The individual will provide technical and scientific expertise in in vivo pharmacology across PBR to enable target identification, validation, and prioritization and efficient drug discovery. Ideal applicants will be collaborative and team-oriented, possess excellent communication, leadership, and organizational skills, and have a commitment to excellence.

Role Responsibilities
  • Work within multi-functional teams to support small molecule drug discovery.
  • Design and conduct in vivo pharmacology studies to evaluate PK, PK/PD, efficacy, and therapeutic index.
  • Develop and characterize new in vivo mouse models, including syngeneic tumor and human cell line/PDX models, to support exploration of novel therapies and to study biological mechanisms.
  • Interpret, present, and document experiments within an electronic lab notebook, as well as prepare reports for regulatory documents such as IND filings.
  • Provide written and verbal presentation of results within a multidisciplinary team environment.

Basic Qualifications
  • PhD in immuno-oncology, oncology, in vivo pharmacology, or a related discipline with 3+ years of post-doctoral experience, or BS/MS degree in oncology or related discipline with 9+ years' relevant experience.
  • Expertise in designing and performing a variety of efficacy and pharmacodynamic studies; experience in contributing to safety pharmacology and toxicology studies is a plus.
  • In vivo pharmacology skills with animal models, including animal handling and restraint, compound dosing, tumor implantation, blood and tissue sampling, small animal surgical techniques, necropsy procedures, and physiological monitoring.
  • Ex vivo and in vitro skills, including flow cytometry, Western blotting, and ELISA.
  • Current knowledge of immuno-oncology and cancer research, with an ability to follow novel scientific/technological developments for implementation in the lab.
  • Proven ability to make important contributions to immuno-oncology, cancer biology, or related fields, as evidenced by a strong publication, funded grant, and/or patent record.
  • Demonstrated ability to work independently.
  • Excellent written and oral communication and presentation skills in English.
  • Proficiency in all common office and scientific software.
  • Strong ability to multi-task and work productively in a fast-paced, highly collaborative, and diverse team environment.
  • Capability to contribute to a vivid and challenging intellectual environment.

Physical Requirements
  • Work requires some exertion and dexterity such as standing, sitting, walking, bending, reaching, lifting light objects, and handling small rodents in the vivarium.

Work Schedule Requirements
  • Must be willing and able to work after hours as needed to ensure study integrity. Travel may be required to attend meetings and conferences.

Other Job Details:
  • Eligible for Employee Referral Bonus
  • Relocation Assistance for eligible candidates


The annual base salary for this position ranges from $80,000 to $133,300. In addition, this position offers an annual bonus with a target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

Similar jobs

Similar jobs