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Senior Scientist, Proteomics

Boulder, Colorado
Closing date
Jul 29, 2021

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Life Sciences, Proteomics, Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Senior Scientist
Organization Type
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Pfizer Boulder Research & Development is currently seeking a highly motivated and team-oriented candidate for a Senior Scientist position to help expand our chemical biology and proteomics capabilities in Boulder, CO. The successful candidate will aid in the development and application of chemical biology and innovative mass spectrometry platforms to drive a deeper understanding of our molecules and cellular targets. Relevant workflows include phospho-proteomic analysis of MAPK signaling pathways in response to various kinase/phosphatase inhibitors, small molecule target deconvolution in phenotypic screen studies, and identification of off-target proteins that have high affinity for our drug candidates.

Job Responsibilities:
  • Apply quantitative protein mass spectrometry technologies for chemo-proteomics and general proteomics across the oncology portfolio
  • Design workflows to detect differences in protein phosphorylation between sample sets (drug-sensitive versus resistant cell lines, drug-treated versus control cells, etc.)
  • Develop methods for direct identification of small molecule-targeted kinases
  • Participate in all aspects of laboratory operations including sample preparation, running samples on the MS, and data analysis and interpretation
  • Collaborate on projects with colleagues in Cell Biology, Structural Biology, and Pharmacology departments
  • Evaluate and implement new technologies/methodologies that may enhance proteomic workflows
  • Develop computational workflows for proteomic data analysis
  • Report data, interpret results, and present at project team meetings

  • Ph.D. in chemical biological engineering, biology, biochemistry, or related field is required
  • Extensive hands-on experience in phosphoproteomics and chemical biology is required
  • Expertise in proteomics-based mass spectrometry methods, including sample preparation and familiarity with quantitative proteomics methodologies (ex. SILAC, TMT) is required
  • Extensive hands-on experience in developing computational workflows for processing and statistical analysis of phosphoproteomics data (using Python or R) is required
  • Hands-on experience and strong trouble shooting skills for high-resolution LCMS analysis
  • Experience interpreting mass spectral data to make structural assignments
  • Excellent oral and written communication skills
  • Excellent interpersonal skills and ability to work in a team environment

Other Job Details

Eligible for Relocation Package

For roles based in Colorado:

The annual base salary for this position ranges from $80,000.00 to $133,000.00. In addition, this position offers an annual bonus with a target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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