GSK

Investigator, LC/MS Protein Characterization

Employer
GSK
Location
Collegeville, PA
Salary
Competitive
Posted
June 20 2021
Ref
294368
Discipline
Other, Other
Organization Type
Pharma
Site Name: USA - Pennsylvania - Upper Providence Posted Date: Jun 20 2021 GlaxoSmithKline has an immediate opening for an Investigator position for HPLC mass spectrometry, proteomics, and protein characterization in Collegeville, PA. This role will be primarily responsible for developing mass spec based strategies & methods (e.g. LC-MS and LC-MS/MS) and performing analysis for the characterization and comparability evaluation of therapeutic proteins. They will also develop and apply methods, including nano-LC-MS/MS, for the identification and analysis of residual host cell proteins [HCPs]. The candidate is also expected to develop other analytical and/or biochemical methods to deepen the understanding of protein structure and function relationships, and participate in supporting FTIH through to commercial biopharmaceutical process development and manufacturing. The mass spec group is well equipped with modern instrumentation including Thermo Eclipse Tribrid, Thermo Exploris 480, Thermo Fusion Tribrid, Waters Synapt G2-S, Waters Xevo G2-XS, Thermo Q Exactive Plus, Agilent 6490 QQQ, Nano-UPLC, UPLC and many other supporting instrumentation and associated data analysis software packages. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: MS with more than 5+ years of experience in biotech or pharmaceutical industry or Ph.D. Experience in protein characterization mass spectrometry, with hands-on experience on various high-resolution accurate mass LC/MS instruments operation, nano-LC fluidics and LC-MS/MS methods, data processing software and workflows. Experience in developing cutting-edge LC-MS/MS workflow for proteomics analysis Preferred Qualifications: If you have the following characteristics, it would be a plus: Experience with host cell proteins (HCPs) analysis Experience with intact, subunit or peptide mapping analysis of protein therapeutics Experience with using or developing data independent analysis (DIA) acquisition schemes and usage of software for the interpretation and statistical analysis of the resulting data Excellent scientific and working knowledge in structure and functions of protein glycosylation, prior experience in glycan and/or glycomics analysis In-depth knowledge and hands-on experience in various separation techniques such as CE, SEC, IEX and HPLC/UPLC Experience in supporting FTIH through to commercial stage of biopharmaceutical development The candidate is expected to be highly motivated with excellent communication skills, both written and verbal. Candidate should be an instinctive team player with excellent people skills. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

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