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Translational and Computational Pathologist

Collegeville, Pennsylvania; Waltham, Massachusetts
Closing date
Jul 28, 2021

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Site Name: USA - Massachusetts - Waltham, USA - Pennsylvania - Upper Providence Posted Date: Jul 16 2021 Are you a Translational and Computational Pathologist keen to work with the AI/ML team to develop computational pathology capabilities and applications with our R & D oncology scientists? If so, this Translational and Computational Pathologist career opportunity is an excellent opportunity to explore. GSK is expanding the Experimental Medicine Unit within the Oncology R & D organization and we are seeking experienced professionals to join our exciting journey. GSK Oncology has a commitment to the discovery and development of new oncology therapies with the life-changing potential of helping patients with cancer, specifically in four areas of cancer research: • Immuno-Oncology: using the human immune system to treat cancer • Cell/Gene Therapy: engineering human T-cells to target cancer • Cancer Epigenetics: modulating the gene-regulatory system of the epigenome to exert anti-cancer effects • Synthetic Lethality: targeting two mechanisms at the same time which together, but not alone, have substantial effects against cancer For more information about GSK Oncology, please visit: Oncology R&D pipeline: GSK Oncology Pipeline GSK 2020 Annual Report: At GSK we see a world in which advanced applications of Machine Learning and AI will allow us to develop transformational medicines using the power of genetics, functional genomics and machine learning. AI will also play a role in how we diagnose and use medicines to enable everyone to do more feel better and live longer. It is an ambitious vision that will require the development of products at the cutting edge of Machine Learning and AI. For more information on AI and ML at GSK, please visit: GSK is seeking a translational and computational pathologist to integrate knowledge of disease mechanisms with drug mechanism of action to inform drug development. The successful candidate will work closely with research & development scientists who discover and develop drugs for the treatment of cancer and discover and develop biomarkers for pharmacodynamic assessment and patient selection for clinical trials. In addition, the successful candidate will work with the AI/ML team to develop computational pathology capabilities and applications in design, validation and construction of novel predictive algorithms based upon anatomic pathology images. The role is embedded within the Experimental Medicine Unit (EMU) in Oncology R&D and works across R&D to ensure that strategies for the treatment and cure of disease are based on accurate analysis of pathogenetic mechanisms. *LI-GSK Key Responsibilities: · Provides expertise in the molecular, cellular, systems biology, and pathogenic mechanisms of disease · Provides pathology expertise and support for drug, biomarker and diagnostic programs in oncology · Applies a broad range of diagnostic modalities and translational pathology tools and technology, including assay or digital pathology image analysis algorithm development · In partnership with the Biomarker Leads within the EMU will evaluate and implement novel tissue-based assays and/or analytical techniques · Aid in integrating data across different diagnostic platforms in partnership with the Precision Medicine & Companion Diagnostics team within the EMU · Applies special skills in anatomic and computational pathology including immunohistochemistry, multiplexed immunofluorescence; ii) Spatial or single-cell transcriptomics iii) Quantitative image analysis including artificial intelligence or machine learning, or iv) Advanced microscopy applications · Works with the EMU and AI/ML organization on the development of computational pathology capabilities and applications, involved in the design, validation and construction of training and validation data · Works with AI/ML organization on the multimodal integration of pathology data with medical imaging, cfDNA, and other data sources. · Interfaces with contract research laboratories and with diagnostic developers to implement anatomic pathology assays and to ensure accurate data interpretation · Contributes to regulatory submission documentation; Represents GSK to regulatory organizations, professional organizations; Interacts with key opinion leaders and contract research organizations (as needed) · Involved in the design of ethical and transparent AI/ML systems Why you? Minimum Qualifications: We are seeking a professional with the following qualifications and skills to achieve our goals: MD with Board Certification in Anatomic Pathology with subspecialty fellowship training or two + years of postdoctoral research experience in oncology Excellent traditional diagnostic pathology skills with a strong ability to interpret pathology data in the context of a deep understanding of molecular and cellular biology. Demonstrated ability to handle several projects at any given time, to work successfully and collaboratively in teams and to communicate clearly both verbally and in writing to a variety of audiences. Preferred Qualifications: MD/PhD Board Certification in Hematopathology or Molecular Genetic Pathology Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigor and risk Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Translating strategy into action - a compelling narrative, motivating others, setting objectives. Building strong relationships and collaboration, managing trusted stakeholder relationships internally and externally. Leadership (expertise, self-awareness, high performance behaviors and ability to execute the assigned role) in a matrix and line environment Embedding a culture of individual empowerment across the broader study team If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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