Senior Associate Scientist, Biophysics

Groton, Connecticut
July 18 2021
Position Type
Full Time
Organization Type

Pfizer currently has a Senior Associate Scientist position opening for a biophysicist in the Structural and Molecular Sciences (SMS) department in Groton, CT. We are an integrated and highly collaborative team of colleagues with technical expertise in molecular biology, protein biochemistry, biophysics, and structural biology. We have a strong track record of enabling hit-to-lead progression for small molecule modulators of both soluble and integral membrane proteins using integrated biophysical and structural approaches. We actively collaborate with Pfizer drug discovery teams across multiple therapeutic areas including Immunology & Inflammation, Internal Medicine, Vaccines, and Rare Diseases, with a mission to advance drug and vaccine discovery efforts by providing comprehensive molecular and structural insights into therapeutic targets, lead molecules, and protein-ligand interactions. The preferred candidate will be a highly motivated and innovative scientist with a desire to pursue challenging biomolecular targets for drug discovery. He or she will have significant experiences in protein science and characterization, as well as innovative and comprehensive approaches in solution biophysics

  • Prepare and manipulate proteins for in vitro assays
  • Apply various biophysical approaches (including SPR, ITC) to enable hit identification, validation, target engagement, and Mechanism-of-Action studies
  • Develop fit-for-purpose assays to triage chemical matter arising from screening campaigns.
  • Oversee the operation, maintenance, and troubleshooting of key technologies and instruments
  • Help to identify, evaluate, and, where applicable, implement novel methods or technologies that would enhance workflow efficiencies and/or improve data quality.
  • Be part of multi-disciplinary teams to support discovery projects across diverse disease areas.
  • Effective oral and written communication of experimental work and analysis.

  • BS or MS with 2-5 years of relevant laboratory experience required
  • Proficient in handling of recombinant protein samples in vitro
  • Previous experience with biophysical assay formats and investigation of target-ligand interactions (ex: binding affinity)
  • Capable of developing new assays, problem solving and advancing innovation in biophysics
  • Working knowledge in various biochemical and structural techniques
  • Ability to multi-task to balance parallel activities


Sitting, standing, lifting, bending, and walking. Ability to perform practical laboratory bench work and work on a computer (while standing or sitting). Ability to perform mathematical calculations and interpret data.

  • Candidate must comply with laboratory safety practices

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


Similar jobs

Similar jobs