Pfizer

Scientist (non-PhD), Immunosuppression

Employer
Pfizer
Location
La Jolla, California
Salary
Competitive
Posted
July 16 2021
Ref
4815127
Position Type
Full Time
Organization Type
Pharma
ROLE SUMMARY

Pfizer Cancer Immunology Discovery (CID) is within the Oncology division of Pfizer Worldwide Research & Development in La Jolla, CA. CID is dedicated to developing new protein therapeutics to improve human life by redirecting the immune system against cancer. CID researchers apply the latest scientific knowledge and novel approaches to discover truly innovative Immuno-Oncology therapeutics. We are seeking to hire Scientist for the CID Immunosuppression group.

ROLE RESPONSIBILITIES
  • Evaluation of novel immunosuppressive mechanisms that confer resistance to anti-tumor immunity
  • Execution of cell-based functional and biochemical assays to select candidate molecules for clinical development
  • Planning and execution of in vivo murine studies and ex vivo functional assessments, such as, complex human tumor/stroma/immune cell 3D assays , multi-color flow cytometry, biochemical assays, I mmunohistochemistry/immunofluorescence, and primary cell culture
  • Communication of experimental results to team


BASIC QUALIFICATIONS
  • B.S. degree with 6+ years' experience or MS (preferred) with 5+ years of experience
  • Experience in the fields of immunology, oncology, cell biology, and/or genetics
  • Ability to plan and execute and in vitro experiments with minimal supervision
  • Expertise in standard immunologic techniques
  • Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, proliferation, and suppression assays by using monocyte/ macrophages, T-cells, or dendritic cells, 3D spheroids, tumor explants and organoid assays that mimic human tumor microenvironment)
  • Experience with human PBMC and mammalian cell culture
  • Experience with flow cytometry (Fortessa and/or Cytek Aurora), qRT-PCR, ELISA, MSD, ELISPOT, alphaLISA, western blotting (Jess), Nano string, or cytotoxic assays (CTG and/or LDH assays)
  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic


PREFERRED QUALIFICATIONS
  • Primary human and mouse immune cell functional assays
  • Experience in working with biologics and small molecules for cancer immunotherapy
  • Immune phenotyping of tumors by flow cytometry
  • Experience in CRISPR technology, lentiviral transduction, tumor explant, and 3D spheroid assays


PHYSICAL/MENTAL REQUIREMENTS
  • Standing, sitting, bending, lifting, walking, and repetitive pipetting in a laboratory or vivarium setting.
  • Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory; additional PPE requirements when working in vivarium barrier suites.
  • Standard business office conditions; sitting, standing as appropriate.
  • Ability to perform mathematical calculations.
  • Ability to read, understand, and perform written protocols, and ability to perform moderately complex data analysis using Microsoft Excel, GraphPad Prism or other similar data analysis software.


NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
  • Occasional off-hour and weekend schedule


OTHER JOB DETAILS
  • Eligible for Employee Referral Bonus


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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