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Senior Scientist, Structural & Molecular Sciences

Groton, Connecticut
Closing date
Jul 25, 2021

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We have an open position at the Senior Scientist level for a cryo-EM position in the Structural and Molecular Sciences (SMS) group at our Groton, CT Pfizer Research and Development campus. The SMS group is a multidisciplinary group with established expertise in molecular biology, protein biochemistry, protein mass spectrometry, enzymology, NMR, biophysics, protein X-ray crystallography and cryo-EM. Our mission is to provide integrated molecular insights into drug targets and their interactions (small and large molecule) to advance discovery efforts across multiple therapeutic areas, including Inflammation and Immunology, Vaccines, Cardiovascular and Metabolic Diseases and Rare Diseases. We are equipped with an FEI Titan Krios microscope, an FEI TF20 microscope, and a dedicated computer cluster and GPU boxes for data processing and refinement. We continue to leverage the capabilities above for broad portfolio support and impact.

As a Senior Scientist, you will have broad experience or familiarity with different aspects of structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and 3-D reconstruction. We are seeking and applicant who is passionate about science in addition to hardware and computing skills associated with EM including microscope, direct electron detector, sample robot, computer cluster, etc. and their maintenance.

Equally important will be your ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams. The successful candidate will have opportunities to grow and develop in structure-based drug design and to identify and tackle the critical issues and challenges faced by different drug discovery programs.

  • As a member of the EM lab, help manage, maintain, and develop the facility, supports users, and lead collaborative projects aimed at improving our cryo-EM infrastructure and scientific research programs.
  • Leverage cryo-EM expertise, provide consultation and guidance to colleagues from other SMS labs for EM studies and serve as a valuable resource for the entire department.
  • Independently undertake cryo-EM studies of targets that are of interest to Pfizer. The proposed work will involve all aspects of cryo-EM structure determination including preparation of suitable grids, analysis by negative staining, cryo-EM data collection, class averaging, 3D-reconstruction and refinement.
  • Deliver novel scientific insights for the design of small molecule ligands as well as protein therapeutics and/or antigens.
  • Establish productive collaborations with other SMS colleagues and form partnerships with colleagues from research units and other departments.
  • Rapidly advance projects by timely problem solving and crisp decision making.
  • Clearly communicate with project team members and other Pfizer colleagues.
  • Consistently record your experimental results in an electronic laboratory notebook and comply with all Pfizer safety policies.

  • Doctoral degree or equivalent in Biochemistry, Biophysics, Physics, Chemistry or related field.
  • 0-3 years of cryo-EM postdoctoral research experience (or equivalent) in academia or industry.
  • Proven ability to independently design and conduct state-of-the-art single particle cryo-EM experiments, leading to a strong track record of successful outcomes with publications in top tier journals.
  • Must be able to thrive and deliver results in a fast paced, dynamic and highly multi-tasking environment.
  • Broad knowledge in protein characterization, structural biology, biophysics and computational chemistry.
  • Demonstrated ability to work independently and in teams in an inclusive manner.
  • Proven scientific influence via strong interpersonal and communication skills; passionate about using structural data to influence key scientific decisions.
  • Has the skill and drive to grow into a thought leader.

  • Eligible for Employee Referral Bonus
  • Eligible for Relocation Package


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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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