Senior Scientist, Antibody Discovery, High-Throughput Screening

Cambridge, Massachusetts
July 16 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist

We are seeking an experienced, highly motivated scientist to become part of a team focusing on assay development and high throughput screening for the generation and identification of novel biotherapeutics. The individual will participate in efforts to develop and integrate cell-based functional assays including, but not limited to, reporter gene, downstream signaling, internalization, proliferation, & apoptosis to address unmet screening needs. Qualified candidates will develop each assay for high-throughput capacity through the use of robotics .

You willparticipate in the continuous improvement and operation of high-throughput integrated platforms composed of liquid handlers, Delfia reader and data capture software (Spotfire). Adapt bench level assays to full automation by developing automated workflows supporting biochemical, cellular, antibody binding and internalization assays. Maintain automation systems and develop new protocols when needed. You will be directly, responsible for programming, operating and maintenance of HTS/HCS platforms. Proficiency in automation scheduling, data collection, data analysis, instrument calibration, maintenance and repairs per scientific and GxP standards is a must.

The successful individual will collaborate with and support various research units for the development of biotherapeutics, and thrive in a fast-paced, team environment. In this position, the successful candidate will work within a matrix, across a portfolio of programs, collaborating with multiple groups including the research units (discovery biology) and several partner lines.

  • Develop cell-based functional assays for high-throughput screening
  • Troubleshoot experimental design and assay optimization
  • Conversion of current biochemical and cell-based assays into HT format
  • Operate and troubleshoot high-throughput integrated automation system, liquid handlers, screening platforms and data capture systems in support of therapeutic projects
  • Work closely with external vendors with regard to new technologies and instrumentation
  • Critically analyze experimental data and present results at internal meetings.
  • Collaborate with the informatics team in design and implementation of streamlined data handling tools.
  • Collaborate with and support the relevant biology research units
  • Ensure all tasks and responsibilities are performed according to scientific and ethical standards and accurately documented in lab notebook

  • MSc in biology, biochemistry or related field with 8-10 years of research experience, or PhD plus 0-5 years research experiencein assay development and high throughput screening, with the ability to succeed in a collaborative, highly matrixed environment.
  • Strong background in assay development techniques for all major cell membrane target classes including GPCRs, transporters, ion channels, etc.
  • Expert level knowledge of assay development methodologies for binding and functional activity
  • Experience with homogenous assay development including HTRF/LANCE/DELFIA/Alpha Screen
  • Experience with different detection technologies including FRET, luminescence (enzyme complementation), fluorescence, and absorbance
  • Experience in molecular biology and cell line manipulation
  • Prior experience with developing routines for, operating, and troubleshooting high-throughput screening, automation and liquid handling platforms
  • Experience with integrated automated platforms such as ThermoFisher's Spinnaker/Columbus or High Res Biosolutions

  • Industry experience within drug discovery (small or large molecule) is a plus
  • Exceptional communication skills, attention to detail and customer focus
  • Demonstrated ability to work effectively as part of a team and to adapt to ambiguity and change

Other Job Details:
  • Last Date to Apply: July 22, 2021
  • Eligible for Employee Referral Bonus: YES


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