Senior Scientist Cell Biologist
Site Name: USA - Pennsylvania - Upper Providence Posted Date: May 6 2021 We are seeking a highly productive and motivated bench scientist with a track record in developing highly sophisticated complex In Vitro Models. These can require organoid technology, applied bio-engineering and/or developing and incorporating microphysiological systems for drug development. The successful candidate will be responsible for seeking, developing, qualifying translational cellular models for higher throughput and lower throughput high complexity models. The candidate would join the Complex In Vitro Models (CIVM) team within In Vitro In Vivo translation (IVIVT) department in GSK's research organization at the Upper Providence site. CIVMs mission is to improve predictive and translational value of preclinical models. We strive to improve models for MOA, efficacy, safety and metabolism, aiming to assess these in the same systems whenever possible. The CIVM group closely collaborates with the research units, the medicinal science and technology (MST) organization and other IVIVT groups. The bench scientist will have the opportunity to work in Immunology based diseases and other disease areas. Key Responsibilities Include, But Are Not Limited To Develop and apply complex in vitro assays including 3D patient derived organoids (PDO), PDX derived organoids (PDXOs) microphysiological systems, 3D bioprinting and organ-on-a-chip approaches for Innate and Adaptive Immunology, Oncology, liver and/or gut models. Routine maintenance and characterization of PDOs and PDXOs Development and application of advanced cellular models incorporating components of the immune system, and will participate primarily in the early profiling of drug candidates across different disease areas. Test the functional consequences of genetic variants in Organoid-based model systems using methods that include CRISPR-based gene editing technologies Perform cell-based assays in combination with imaging technologies on organoids to support small or large molecule and cell therapy drug programs. Work in a matrix team environment to ensure optimal delivery of project and department objectives to the highest possible scientific standard Independently execute laboratory experiments, apply advanced data analysis, integration and interpretation with an emphasis on providing appropriate context for data and experiments in order to progress programs and/or develop platforms Train lab personnel in Organoid Technology Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: MS in a related field with 2+ or a BS with 4+ years of experience. Experience in developing cellular or 3D assays for drug discovery projects Experience with a broad range of cell biology technologies Preferred Qualifications: If you have the following characteristics, it would be a plus: Experience working with organoids Assay Implementation, development, and automation in a pharmaceutical drug discovery setting Experience in developing and qualifying complex in vitro models that are 3D tumor, vascularized, or epithelial barrier models Excellent verbal and written communication skills Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. 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