GSK

Investigator, Metabolomics

Employer
GSK
Location
Collegeville, PA
Salary
Competitive
Posted
May 04 2021
Ref
282005
Discipline
Other, Other
Organization Type
Pharma
Site Name: USA - Pennsylvania - Upper Providence Posted Date: May 4 2021 GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. We have an exciting new position available within the MS Bioimaging group at GSK, based from our world-class R&D site at Collegeville, PA. Our group is currently building new capabilities to assess spatial metabolomic and lipidomic changes in tissues to provide insight into mechanisms of pharmacology and toxicity. This new role will focus on development of LC-MS/MS based omics workflows and support integration of this data with non-targeted imaging mass spectrometry (IMS) analyses. We are looking for a candidate with extensive experience and deep technical expertise in LC-MS/MS based metabolomic and/or lipidomic workflows, specifically in data acquisition, processing, analysis, and interpretation with a broad knowledge of biological pathways. The successful candidate will join a highly collaborative and motivated team of scientists focused on providing innovative solutions to help deliver safe and efficacious new medicines to patients. Bioimaging at GSK The Bioimaging department brings together key areas of in vivo and ex vivo imaging combined with histology to understand both disease state and intervention, combining data on drug distribution with the effect that distribution has on intact biological systems. At GSK we believe that the fewer barriers there are in delivering the science, then the better our delivery of new medicines to patients. As part of the wider In Vitro/In Vivo Translation platform we encourage enterprise collaboration as well as external partnership with the wider scientific community to achieve our full potential. Key Responsibilities: LC-MS/MS based metabolomic and lipidomic workflows in support of non-targeted IMS analyses to deliver functional pharmacology mechanistic endpoints for projects and enhance understanding of biological systems Develop molecular identification strategies using tissue extracts and tissue surface analysis methods (e.g. LESA) to achieve accurate molecular assignment from MALDI imaging data Work in partnership with the Imaging Analytics teams and other stakeholders to build data repositories and custom pipelines to achieve streamlined identification of endogenous biological molecules and cellular pathways, and facilitate broader data reuse Work in partnership with project teams to understand project issues, provide input and report data to matrix teams, including close networking with all imaging groups across GSK. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: PhD in Chemistry, Biology, Physical Sciences, or related discipline. Experience in LC-MS/MS-based metabolomics and/or lipidomics data acquisition and analysis Experience with common identification strategies for endogenous biological molecules Experience with troubleshooting and maintaining complex instrumentation Preferred Qualifications: If you have the following characteristics, it would be a plus: Basic understanding of imaging mass spectrometry Experience with Thermo or Bruker mass spectrometers Evidence of effective, collaborative interpersonal, organizational and communication skills, both oral and written, for working in a multi-disciplinary scientific team environment. Established track record with scientific presentations and publications Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

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