Research Associate II - Molecular Diagnostics for Alcohol Use Disorders

Duarte, California
July 08 2021
Position Type
Full Time
Organization Type
Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions.

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

A Research Associate II (RAII) position is available in the Lab of Dr. Tijana Jovanovic-Talisman. The position will focus on probing mechanisms of alcohol use disorders. Long-term alcohol abuse may lead to cancer and limit the life span of an individual by more than 20 years. Unfortunately, the scarce therapies that exist for treating alcohol use disorders are marginally effective. One challenge in developing new treatments is that alcohol does not bind to specific receptors. Rather, it perturbs the dynamics of protein-lipid interactions in the plasma membrane. To identify potential new therapeutic approaches, our laboratory has been probing the disorder at the molecular level. Using super-resolution microscopy in cultured cells and rat brain slices, our goal is to define the nano-organization of opioid receptors and relevant components of the plasma membrane. We expect this molecular level data to open avenues towards new treatments for alcohol use disorders.

Key Responsibilities include:

The RAII will work with cell culture and immunostain cells and rat brain slices. The RAII will use super-resolution microscopy and perform data analysis approaches to define the nano-organization of relevant biomolecules.

Basic education, experience and skills required for consideration:
  • Bachelor's degree. Master's degree preferred
  • Two years related research/ laboratory experience with a Bachelor's degree or

One year related research/ laboratory experience with a Master's degree
  • Experience in microscopy and cell biology
  • MATLAB experience is preferred

Additional Information:

About Dr. Jovanovic-Talisman: Tijana Jovanovic-Talisman, PhD is an Associate Professor in the Department of Molecular Medicine . Dr. Talisman currently has multiple projects actively supported by the NIH. She and team are investigating biological processes that are critical to the progression of cancer and other diseases by using quantitative single molecule localization microscopy.

For more information on the Jovanovic-Talisman Lab, please click here .

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

  • Posting Date: May 10, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job

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