Postdoc or Instructor position for cancer genetics, cancer immunology, and molecular cancer biology

Location
Pittsburgh, Pennsylvania
Salary
Based on experience
Posted
June 30 2021
Position Type
Full Time
Organization Type
Academia

A Postdoc or research instructor faculty position is available at Wang Laboratory of the UPMC Hillman Cancer Center, University of Pittsburgh. The individual will be working on our leading-edge integrative genomics initiatives aimed at identifying pathological genetic aberrations and immunological targets from multi-dimensional cancer genomics datasets. The candidate will receive unique multidisciplinary training on cancer genetics, molecular cancer biology, precision immuno-oncology, computational genomics, and translational research. The candidate must hold a Ph.D. degree. A preference will be given to highly motivated candidates with an outstanding publication record in cancer research, and those with established expertise in cancer immunology, molecular cancer biology, or cancer cell biology.

The research project for this position will interface the “dark side” of cancer genetics with cancer immunology. Specifically, the candidate will investigate a cryptic class of adjacent gene rearrangements in more aggressive and therapy-resistant forms of breast, ovarian, or other epithelial cancers, and examine their function in cancer progression and/or immunotherapy resistance. The primary responsibilities will include experimental validation of newly discovered genetic targets, characterize their molecular basis, elucidating their clinical significance using patient samples, confirming their role in tumor progression, immune disfunction, or therapy resistance in vitro and/or in vivo, pinpointing their mechanistic basis, and exploring potential clinical applications.

Wang laboratory is a computational genomics and translational cancer research lab at UPMC Hillman Cancer Center, Department of Pathology, University of Pittsburgh. Our lab is dedicated to the discovery and characterization of novel breast cancer genetic targets from multi-dimensional genomic datasets to achieve precision therapeutics. Our research projects have been funded by NIH/NCI, Department of Defense, Susan G. Komen Foundation, and Commonwealth of PA, and our studies have led to high-profile publications in Nature Biotechnology, Nature Communications, PNAS, Cancer Discovery, Cancer Research, and Clinical Cancer Research, etc. Our postdoc trainees have received four prestigious postdoc fellowship Awards including two awards from Susan G. Komen Foundation and two awards from Department of Defense.

As our major achievements, our lab have identified two recurrent gene fusions ESR1-CCDC170 and BCL2L14-ETV6 in luminal B and triple-negative breast cancer, respectively -- the only two canonical gene fusions identified in major breast cancer entities to date. In addition, our lab has characterized two novel breast cancer kinase targets, NLK and TLK2, and preformed preclinical studies of their inhibitors. As part of our immunogenomics research, we have developed an innovative HEPA-PARSE approach for high-throughput identification of tumor associated antigen targets. Our research projects are backed up with topnotch computational infrastructure, outstanding research facilities, and vast clinical sample repositories at University of Pittsburgh and the Cancer Center. For more information, please visit http://www.cagenome.org/lab.

To apply, please send your CV, cover letter, and the contact information of 3 referees to:

Xiaosong Wang, M.D., Ph.D.

Associate Professor of Pathology

UPMC Hillman Cancer Center

Email: xiaosongw@pitt.edu

Review of applications will begin immediately until these positions are filled. The University of Pittsburgh offers a comprehensive salary program and excellent benefits in a smoke and drug free workplace. University of Pittsburgh School of Medicine is an Affirmative Action/Equal Opportunity Employer and encourages applications from under-represented groups.

Apply for Postdoc or Instructor position for cancer genetics, cancer immunology, and molecular cancer biology

Already uploaded your resume? Sign in to apply instantly

Apply

Upload from your computer

Or import from cloud storage

Your Resume must be a .doc, .pdf, .docx, .rtf, and no bigger than 1Mb


Upload from your computer

Or import from cloud storage

Your Supplementary Documents must be a .doc, .pdf, .docx, .txt, .rtf, and no bigger than 1Mb


4000 characters left

Marketing Communication

We'd love to send you information about Jobs and Services from Science Careers by email.

All emails will contain a link in the footer to enable you to unsubscribe at any time.


When you apply for a job we will send your application to the named recruiter, who may contact you. By applying for a job listed on Science Careers you agree to our terms and conditions and privacy policy. You should never be required to provide bank account details. If you are, please email us.

Similar jobs

Similar jobs