Postdoctoral Fellow Positions

Medical University of South Carolina
Charleston, South Carolina (US)
NIH Postdoctoral scale; commensurate with experience.
June 28 2021
Organization Type
Job Type

Postdoctoral Fellow Positions

Department of Cell and Molecular Pharmacology 

& Experimental Therapeutics

Hollings Cancer Center

Charleston, SC

The O’Bryan and Hobbs Labs are seeking multiple highly motivated individuals to work in the area of cellular signaling related to cancer development and progression. Candidates must have experience in molecular biology, biochemistry, and cell biology. Research in the laboratories is focused on two major areas: 1. Direct inhibition of RAS signaling and transformation using novel biologics; and 2. Developing and inhibiting allele-specific RAS downstream signaling and metabolic alterations. The O’Bryan group has identified vulnerabilities in oncogenic RAS using novel biologics and are using these powerful tools to develop new therapeutic strategies to inhibit RAS-driven cancers (Spencer-Smith et al, Nat Chem Biol., doi: 10.1038/nchembio.2231; Khan et al Oncogene doi: 10.1038/s41388-018-0636-y; Khan et al, Small GTPases, dox: 10.1080/21541248.2021.1906621). Current studies are examining the importance of RAS dimerization/nanoclustering in activation of RAS effector pathways, using novel affinity reagents to probe isoform-specific differences in RAS signaling, and identification of small molecule RAS inhibitors. The Hobbs Lab has identified that KRAS G12R, a KRAS mutation specific to pancreatic cancer, has unique effector binding and metabolic perturbations (Hobbs et al Cancer Discovery doi:10.1158/2159-8290.CD-19-1006.). Current studies in the lab involve targeting these metabolic and signaling dependencies in KRAS-mutant pancreatic cancer as well as determining other RAS allele-specific signaling differences and vulnerabilities.

Applicants must have a Ph.D. or M.D. degree, and be eligible for employment in the U.S. Preference will be given to candidates with strong skills in molecular biology, biochemistry, tissue culture, and animal work. These are non tenure-track positions, with renewal dependent on successful progress and continued funding. Start date is negotiable although preference will be given to candidates that can begin immediately. Salary range is commensurate with experience according to NIH scale for postdocs. Position is a benefit eligible position. For fullest consideration send electronic file containing statement of research interest and experience, curriculum vitae, and names of three references to: Dr. John P. OBryan, email: obryanjo@musc.eduDr. G. Aaron Hobbs, email:

Founded in 1824, The Medical University of South Carolina (MUSC) is now the core of the state’s largest medical complex and one of its largest employers with over 11,000 employees. Our research laboratory space exceeds 1 Million square feet. Extramural research funding awards to MUSC in 2017 exceeded $250 million. In addition, MUSC was named on Forbes first-ever list of America’s Best Employers for Diversity.

The Hollings Cancer Center (HCC) is the only NCI-Designated Cancer Center in South Carolina. Currently, HCC researchers hold approximately $45 Million in annual extramural cancer research funding with $23 Million originating from the NCI.

MUSC is located in historic Charleston, South Carolina. The weather is beautiful year-round, with temperatures rarely dropping below freezing during winter. There are several beaches within minutes of the city and the mountains are only three hours away. In addition to these amenities, the art, history, food, and festivals make Charleston an outstanding place to live.

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