Scientist, Biochemistry/Enzymology

La Jolla, California
June 21 2021
Position Type
Full Time
Organization Type
Role Summary

At Pfizer, we both innovate and harness the scale - tremendous expertise and resources - to deliver breakthroughs to make the world a healthier place. Research and Development is at the heart of the Pfizer's purpose as we work to translate advanced science and technologies into breakthroughs that change patient's lives. Pfizer Oncology is a priority therapeutic area - dynamic, innovative, and collaborative. We are committed to discovering, investigating, and developing transformative therapies that improve the outlook for cancer patients.

Biochemistry and Quantitative Pharmacology Department of the Pfizer Oncology Research Division in La Jolla, CA has an immediate opening for an innovative, passionate scientist to join our drug discovery team. This Biochemist will make key contributions to the discovery of future cancer drugs through kinetic, mechanistic, and functional characterization of enzymes and other regulatory proteins, development and execution of focused biochemical / binding and selectivity assays, and ligand SAR analysis. This colleague will serve as both a technical and scientific resource on multi-disciplinary drug discovery project teams.

Role Responsibilities:

  • Develop a variety of impactful robust, automated plate-based biochemical and binding assays and innovative selectivity screens using best available technologies and equipment.
  • Assay execution, data analysis and publication of highly reproducible data.
  • Kinetic and mechanistic characterization of lead compounds and biochemical pathways.
  • Collaborate with diverse project teams to correlate biochemical, cellular, and in vivo data to support progression of small molecule medicines to clinical studies
  • Active engagement across cancer drug discovery activities and on project teams.

Basic Qualifications:
  • Bachelor's with 6-9 years of experience or Master's degree with 4-7 years of work experience.
  • Solid understanding of biochemical/biophysical sciences, methods, and technologies
  • Drug discovery research experience focused on enzymes or other biological targets and their molecular interactions with small-molecule ligands.
  • Extensive experience in assay development and characterization of inhibitor-protein interactions.
  • Strong technical and computational abilities.
  • Excellent interpersonal and communication skills.

Preferred Qualifications:
  • Inquisitive and ambitious BS/MS Biochemist who contributed to exciting biochemical projects.
  • Diverse knowledge and skills in cancer drug discovery, enzymology, and biochemical pharmacology
  • Basic knowledge of cell signaling pathways.
  • Strong technical abilities and skills in developing and performing automated plate-based pharmacology assays, enzyme kinetics, understanding inhibitor SAR.
  • Experience in biophysical methods (e.g. SPR) is a plus.

Other Job Details:
  • Eligible for Employee Referral Bonus

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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