Senior Scientist, Medicinal Chemistry and Molecular Design

Cambridge, Massachusetts
June 21 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist
Would you like to discover the medicines of the future?

At Pfizer we deliver Breakthroughs That Change Patients Lives . In the Medicine Design group we play a vital role in this mission through the discovery of Pfizer's small molecule and synthetically-derived drugs. We are seeking leaders in Medicinal Chemistry to join our world-class Medicine Design team in Cambridge MA to build upon our rich history of innovation in Medicinal Chemistry and Molecular Design and deliver Pfizer's drugs of the future.

Discovering new medicines at Pfizer takes teams with a diversity of skills, behaviors and approaches. Creativity, scientific excellence, tenacity, passion, hard work, organization, teamwork, courage, open-mindedness, curiosity - are just some of the traits successful Drug Discovers display at Pfizer, and we are looking for ambitious Medicinal Chemists, eager to see their work lead to important new medicines and scientific breakthroughs, to join our team.

The Medicine Design group in Pfizer comprises experts in the major scientific disciplines involved in the discovery and preclinical development of small molecule drugs: molecular design, synthesis, computational chemistry, pharmacology, chemical biology, structural biology, biophysics, DMPK and analytical chemistry. We have long been renowned not only for delivering high quality drug candidates into the clinic but also for establishing new drug design approaches and principles, such as the "Rule of 5" and property-based drug design, that have raised the bar of quality in the discipline and been widely-adopted across the industry.

As a Senior Scientist in Medicinal Chemistry and Molecular Design at Pfizer you will play a key role in large, multi-disciplinary matrix teams from project inception through to delivery of clinical drug candidates. You will also contribute to teams of scientists looking to combine Pfizer's expertise and large-scale research investments, with external academic and biotech collaborations, to revolutionize our approach to the discovery and development of small molecule and synthetically-derived drugs.

Role Responsibilities
  • Application of contemporary data analysis and design tools to drive effective target design and prioritization within a project
  • Effective use of both internal & external design resources available to the project team
  • Devise effective hit ID strategies to move projects through the Hit-to-Lead phase with scientific excellence, efficiency and speed
  • Play a key role in progressing projects through the Lead Optimization phase in partnership with enabling functions within Medicine Design to ensure the delivery of small molecule/synthetic drug candidates with scientific excellence, efficiency and speed
  • Contribute to the identification of new small molecule projects to the portfolio through collaborations with disease area biologists
  • Play a role in enhancing the external reputation of Pfizer's Medicinal Chemistry, Molecular Design and synthetic Drug Discovery capabilities through publications and presentations at leading conferences
  • Work with local leadership to put in place an active program of self-development in medicinal chemistry skills


Basic Qualifications
  • Doctorate level degree in relevant area of science, or equivalent experience
  • Examples of strong learning agility and problem solving from scientific work to date
  • A strong desire to gain a contemporary knowledge of the key Medicinal Chemistry concepts and design tools required for pharmaceutical drug discovery
  • Examples of peer-reviewed publications from scientific work to date

Preferred Qualifications
  • Examples of high impact publications from scientific work to date
  • Experience of working in teams of scientists to deliver objectives
  • Exposure to some element relevant to medicinal chemistry from scientific work to date

Along with a Resume/CV, please include a short research summary of your relevant research.

Additional Job Information:
  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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