Pfizer

Scientist - Pilot Plant

Employer
Pfizer
Location
Chesterfield, Missouri
Salary
Competitive
Posted
June 10 2021
Ref
4814984
Position Type
Full Time
Organization Type
Pharma
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

ROLE SUMMARY

The Scientist is a position within the Bioprocess Research & Development (BRD) group responsible for technical engineering and manufacturing support in the Chesterfield Manufacturing Facility. This facility is responsible for manufacturing starting materials and drug substances derived from mammalian and microbial culture process, including vaccines and gene therapy products. This individual will work with project teams to ensure proper technical transfer of incoming complex processes (both upstream and downstream) and oversee technical operations for these projects in the manufacturing area. The Scientist will work closely with the manufacturing technicians to provide appropriate batch records and instructions and ensure that all unit operations are completed to meet on-time delivery of key project supplies. This position also requires fostering strong relationships with other groups within Pfizer including Pfizer Global Supply and Global Workplace Solutions.

This position is responsible for identifying efficiency improvements from an engineering perspective, and planning and supervising the implementation of these improvements within the operational area. The individual may also be responsible in evaluating and implementing new technology.

How You Will Achieve It

  • Scale-up and development of unit operations for biologics manufacturing.
  • Generation of process batch records, acquisition of raw materials, and the purchase, installation, and start-up of new capital equipment.
  • Oversee (from a technical perspective) unit operations in the manufacturing facility for biologics projects.
  • Guide junior technicians/engineers to make correct decisions during the course of daily operations.
  • Data mining and evaluation of process data, modeling, and the generation of reports to support manufacturing.
  • Contribute to internally reviewed technical reports and make internal presentations to scientists and management and external presentations to showcase manufacturing operations.
  • Execute operational efficiency improvements and plan and implement improvements across Bioprocess R&D work processes.
  • Support of GMP manufacturing functions such as Operational Qualification of equipment, cleaning validations, manufacturing investigations, product changeover, etc.



Qualifications

Must-Have

  • B.S./M.S. in Chemical/Biochemical Engineering, or Cell Biology, Biochemistry, Microbiology and 6+ years of industry experience.
  • Experience in a wide variety of heterologous expression systems with a focus on E. coli and CHO cells.

- OR -
  • Experience developing and executing relevant recovery and purification processes derived from microbial and/or mammalian production cultures.
  • Experience in supporting the scale-up and tech transfer from development laboratory to pilot scale manufacturing.
  • Knowledge of GMP and Biotechnology CMC regulatory requirements.
  • Demonstrated key participation on multi-disciplinary manufacturing teams.
  • Excellent oral and written communication skills, and the ability to mentor junior staff and peers.


PHYSICAL/MENTAL REQUIREMENTS

Must be able to lift 40 lbs.
Relocation support available

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development