Senior Associate Scientist

Cambridge, Massachusetts
June 10 2021
Position Type
Full Time
Organization Type

The Internal Medicine Research Unit (IMRU) is committed to the search for new approaches to the treatment of metabolic dysfunction and cardiovascular diseases. Our goal is to build a research team of driven scientists focused on developing a deep mechanistic understanding of the metabolic pathways driving Nonalcoholic Steatohepatitis (NASH), cachexia, obesity, diabetes and cardiovascular disease. The in vivo pharmacology group is part of IMRU and focuses on utilizing scientific approaches to drive and coordinate in vivo efforts to test research hypotheses, identify and validate therapeutic targets, and deliver critical in vivo data packages. Our efforts span the early drug discovery process including pre-clinical in vivo model development, evaluation of disease pathology, pharmacological evaluation and development of in vivo imaging and continuous monitoring platforms aimed at translations to the clinic. We aim to recruit a scientifically and technically exceptional in vivo research scientist to play an important role in our team and contribute to our mission.


We seek an accomplished Scientist to join the in vivo pharmacology group within IMRU. The successful candidate will join a dynamic team of scientists and assume a role in providing in vivo technical expertise across IMRU. He/she will be contribute to in vivo studies with a focus on metabolic derangements, help other team members and provide surgical expertise in preclinical space. The successful candidate will work in a matrix environment and partner with biology teams to design in vivo studies and execute key experiments to ensure efficient decision-making and timely progression of drug development. He/she will also be a key contributor towards preclinical model development for cachexia and cardiometabolic disorders. Ideal applicant will possess excellent communication and organizational skills, critical problem-solving abilities, and a commitment to excellence.

Successful candidates will be expected to:
  • Contribute to design, plan and execute complex in vivo studies and act as point of contact for various platforms and surgical procedures.
  • Perform surgical procedures to wide array of in vivo work, including peripheral and CNS surgeries.
  • Closely work with teams, execute relevant studies and analyze data from in vivo efficacy, pharmacokinetic/pharmacodynamic and biomarker studies.
  • Help develop in vivo model systems and keep abreast of advancements that can be applied to drug discovery and candidate characterization.
  • Communicate scientific progress to different teams and biology leads.
  • Help employ in vivo biology to explore novel hypotheses, evaluate candidate molecules and investigate mechanism of action.
  • Train and mentor in vivo biologists, maintain compliance and ethical standards.

  • BS/MS with 2+ years of pre-clinical in vivo work is required preferably in industry settings.
  • Survival surgical experience is highly desired.
  • Must be proficient in murine handling, dosing (PO, IV, IP, SC), survival sample collection, necropsy and tissue harvesting.
  • Hands-on experience with in vivo cachexia and/or heart failure models and their application in evaluating therapeutic effects is a plus.
  • Experience in heart failure animal models include TAC, MI, Ang II models is a plus.
  • Experience in cancer cachexia animal models, cell and tissue implementation and other relevant surgical skills.
  • Familiarity with drug discovery is a plus.
  • Must be a scientifically self- motivated, capable of independently conceiving, conducting, and critically analyzing his/her own innovative research with minimal supervision.
  • Continued desire to learn novel skills and able to flourish in a highly-matrixed organization as well as work well within multidisciplinary teams.
  • Ability to make recommendations to effectively resolve issues by using sound judgment that is consistent with standards, practices, policies, procedures and regulations.

  • Physical requirements to perform in vivo studies and molecular biology lab work.

Other Job Details:
  • Last Date to Apply for Job: June 16, 2021
  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus

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Research and Development

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