Pfizer

Senior Scientist, High Content Imaging in-vitro Pharmacology

Employer
Pfizer
Location
Groton, Connecticut
Salary
Competitive
Posted
June 09 2021
Ref
4814376
Position Type
Full Time
Organization Type
Pharma
Job Type
Senior Scientist
ROLE SUMMARY

Pfizer colleagues have many perspectives, many backgrounds, and many strengths, but we share one goal: to improve the lives of patients. We are looking for a highly motivated individual to join a team of ~50 scientist within the Primary Pharmacology Group (PPG) at our Groton, CT Campus, focused on the design, development and execution of in vitro plate based screening assays supporting hit identification and lead optimization for small molecule drug discovery programs across Pfizer research units. Working collaboratively with project teams and PPG colleagues, the successful candidate will join the High Content Imaging screening facility to support both target-based and phenotypic programs. This candidate will play a leading role in developing and validating robust high content imaging and/or high throughput flow cytometry assays using physiologically relevant disease models.

Applicants should have strong personal drive and leadership skills to work independently in a highly robotized high content imaging laboratory setting. Importantly, the candidate should have a strong background in cell biology and biochemistry and should be able to rapidly become proficient with new technologies, equipment, and data analysis software. Key to this role is the ability for the candidate to work with complex, multi-parameter datasets and propose creative approaches to challenging technical and biological questions. They will work in project teams with talented scientists from other disciplines (e.g. Chemistry, Research Unit Biology, Structural Biology and CROs) and should therefore possess very strong collaborative and communication skills to build productive partnerships.

The Primary Pharmacology group offers a supportive environment for colleagues, and fosters a culture that encourages openness, innovation and ownership of our science. We aim to provide scientific and growth opportunities for professional development commensurate with a colleague's goals and experience.

ROLE RESPONSIBILITIES

Successful Candidates will be expected to:
  • Support Hit identification and lead optimization for small molecule drugs discovery programs.
  • Contribute to the design of in vitro pharmacology strategies for target-based and phenotypic projects.
  • Design, optimize and perform high content imaging and/or high throughput flow cytometry assays using physiologically relevant disease models to drive small molecule hit identification and optimization.
  • Develop and implement automated image analysis algorithms and data analysis processes.
  • Review and interpret high content data results to project teams
  • Mentor and inspire less experienced colleagues across the Primary Pharmacology Group and Discovery Sciences department
  • Explore and implement cutting-edge science using novel technologies and analytic methods applied to portfolio advancement
  • Work with interdisciplinary teams of disease biologists, medicinal chemists, structural biologists as well as external partners.


BASIC QUALIFICATIONS

  • PhD in Biology or equivalent with 2+ years of experience relevant to drug discovery
  • Microscopy or high content imaging expertise
  • Excellent computer skills and image analysis software experience


PREFERRED QUALIFICATIONS
  • Experience with high content imaging and/or high throughput flow cytometry in vitro assays, including designing experiment and troubleshooting.
  • Practical experience in cell culture and laboratory automation (e.g. liquid handling, automated incubator)
  • Familiar with Image analysis and data analysis software (e.g. Columbus, CellProfiler, GraphPad prism, Spotfire, GeneData Screener)
  • Experience in physiologically relevant disease models and/or 3D culture.
  • Knowledge of associated disciplines such as molecular biology, functional genomics (siRNA, CRISPR), protein chemistry, biophysical techniques, and chemistry.
  • Demonstrated ability to multitask, prioritize work and forge strong relationships inside and outside organizational walls.


PHYSICAL/MENTAL REQUIREMENTS
  • Ability to stand at a lab bench or instrument for extended periods. Sitting, standing, lifting, bending, and walking.
  • Ability to work on a computer, perform mathematical calculations and interpret data


NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
  • Candidate may occasionally be asked to travel to other Pfizer research sites to meet project team members and/or external collaborators
  • Candidate must comply with laboratory safety practices and wear personal protection equipment as required


OTHER JOB DETAILS
  • Eligible for Employee Referral Bonus
  • Eligible for Relocation Package


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Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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