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Postdoctoral Fellow, Structural Biology and Biophysics

Employer
Pfizer
Location
Groton, Connecticut
Salary
Competitive
Closing date
Jun 16, 2021

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Discipline
Life Sciences, Biology, Biophysics, Structural Biology
Position Type
Full Time
Job Type
Postdoc Fellowship
Organization Type
All Industry, Pharma
ROLE SUMMARY

We are seeking an enthusiastic and driven postdoctoral fellow to join the Structural and Molecular Sciences (SMS) Department at the Pfizer campus in Groton, Connecticut. This fellowship offers the unique opportunity to learn about the drug and vaccine development process in the laboratories of an innovative industry leader. The successful candidate will receive state-of-the-art training in protein structural biology and biochemistry with access to unparalleled resources supporting prokaryotic and eukaryotic protein expression, purification, and structure determination by both X-ray crystallography and cryo-EM. At SMS, we have regular access to all the major synchrotron beam lines in the world and dedicated in-house cryo-EM facilities. Ideal candidates will have extensive experience in molecular biology, protein expression, protein purification, and structure determination.

ROLE RESPONSIBILITIES
  • Purification and assembly of challenging protein-protein, protein-RNA and protein-small molecule complexes
  • Iterative design and cloning to generate protein expression constructs
  • Protein crystallization, data collection, and structure determination
  • Cryo-EM sample preparation, data collection, and structure determination
  • Structural analysis to generate and test hypotheses
  • Functional characterization of protein complexes by biophysical and biochemical methods
  • Collaboration across departments
  • Critical reading of the relevant literature
  • Manuscript preparation and presentation of results in oral and poster formats


BASIC QUALIFICATIONS
  • PhD in Structural Biology or Biochemistry with experience in the gene-to-structure pipeline
  • Construct design and molecular biology skills
  • Extensive experience in protein expression and purification
  • Experience with structure determination by X-ray crystallography and cryo-EM
  • Strong track record of publication in peer-reviewed scientific journals
  • Excellent verbal and written communication skills


PREFERRED QUALIFICATIONS
  • Experience in biophysical and biochemical assay development


Relocation support available

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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