The Reproductive Endocrine Unit (REU) at Massachusetts General Hospital (MGH), a Harvard affiliate, is seeking an enthusiastic and ambitious full-time postdoctoral fellow who demonstrates an interest in reproductive medicine, biology, and genetics.
The mission of our lab focuses on improving the understanding the mechanistic drivers of rare reproductive disorders of human infertility through human genomics, transcriptomics and phenomics. Through increased knowledge about the architecture of infertility, we strive to conduct research that will ultimately lead to meaningful improvements for the care of individuals impacted by the diagnoses we study. To accomplish this work, our lab employs a combination of clinical assessments, physiological studies, large-scale genomic sequencing (DNA, RNA, epigenetic), and functional validation leveraging both patient derived specimens and in vitro/in vivo modeling. Our lab is fortunate to have the opportunity to closely collaborate with physicians and investigators across the globe to create unique clinical cohorts with comprehensive clinical examinations, electronic medical records, biospecimens, and continuing clinical follow-up.
Our laboratory is part of a National Center for Translational Research in Reproduction and Infertility, funded by the National Institute of Child Health and Development (NIH). The Unit is also a new recipient of a Gates Foundation Grand Challenge Award. Dr. Seminara, Unit Chief, is PI on a NIH Merit Award which provides 10 years of funding for her translational studies. Thus, the Unit is securely funded for the next 10 years and is eager to welcome a post-doctoral research fellow for a multi-year professional experience.
Currently, we are interested in recruiting postdoctoral fellow with experience in human induced pluripotent stem cell (hiPSC) derivation and cell model work. We are currently generating hiPSC derived GnRH neurons. We want to investigate the cellular and molecular consequences of genetic variation on GnRH neurons by comparing and contrasting the GnRH transcriptome, morphology, migratory capability and secretory function between wild-type and edited GnRH neurons. This project, along with other work from our Unit and its collaborators, will aid in the diagnosis and management of infertility, inform genetic risk prediction for infertility conditions, and facilitate the development of novel therapeutic options for infertility.
Special Instructions to Applicants:
- Applicants should email their CV and contact information, along with a 1-2-page cover letter. Stephanie Seminara, MD, Chief, Reproductive Endocrine Unit, Massachusetts General Hospital, and her assistant, Allison McDermott (firstname.lastname@example.org; email@example.com). The cover letter should outline the applicant’s technical skills, why they are interested in our research, and their reasons for pursuing a postdoc position.
- We will start an application file for you and serve as your points of contact for questions/concerns.
- You will be directed to an online application which is simple to complete. It will prompt you to upload a brief personal statement and two letters of recommendation.
- As soon as those materials are in place, your application will be reviewed by the collective faculty of the Reproductive Endocrine Unit.
PRINCIPAL DUTIES AND RESPONSIBILITIES: Indicate key areas of responsibility, major job duties, special projects and key objectives for this position. These items should be evaluated throughout the year and included in the written annual evaluation.
The postdoctoral research fellow will, under the direction/guidance of a Dr. Stephanie Seminara, assume responsibility for a specific research project. It is expected that this individual will conduct independent scholarly research and will contribute directly to the overall research goals of the project and the research group. The postdoc will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. The postdoc will also be expected to acquire manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at institutional and national meetings. Postdoctoral fellows also may be required to develop new methods and protocols for research and assist with the other research projects in the lab and unit.
QUALIFICATIONS: MUST be realistic, neither overstated nor understated, and related to the essential functions of the job.
- Doctorate (MD, PhD, or MD/PhD) and experience in iPSC derivation and cell model work
- US citizen or Permanent US Resident
- Demonstrable academic and scientific achievements
- Collaborative and collegial spirit
- If English is not your native language, you must demonstrate fluency in both written and spoken English by completion of either the TOEFL or the IELTS, with a minimum score of 100 or 6.5, respectively.
Massachusetts General Hospital is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, creed, sex, sexual orientation, gender identity, national origin, ancestry, age, veteran status, disability unrelated to job requirements, genetic information, military service, or other protected status.
SKILLS/ ABILITIES/ COMPETENCIES REQUIRED: MUST be realistic, measurable, objective, and related to the essential functions of the job.
- Successful candidates will have earned a Ph.D. or equivalent in genetics, molecular biology, cellular biology, or related fields.
- Demonstrated the ability to complete research projects independently.
- Able to work both independently and within a collaborative team environment.
- Design, execute, and record laboratory experiments; apply standard scientific protocols to experiments, research, and improve current methods and evaluate innovative techniques.
- Maintain accurate and detailed records of all laboratory work and experiments.
- Maintain an integral role in the laboratory's meetings, presentations, and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs, and seminars.
- Demonstrate proficient oral and written communication skills and the enthusiasm to work in a multidisciplinary and collaborative environment.
- Vigorously pursue scientific projects, both conceptually and experimentally, with pro-active thinking and action.
- Undertake relevant coursework required by mentor and institution.
- Demonstrate self-motivation, be independent in task completion, and comfortable accepting feedback and guidance from colleagues.
- Demonstrate ability to honor deadlines.
- Have experience in performing cell-based assays.
- Have experience with brightfield and fluorescence microscopy.
WORKING CONDITIONS: Describe the conditions in which the work is performed.
Standard research laboratory (wet lab) environment.
SUPERVISORY RESPONSIBILITY: List the number of FTEs supervised.
Department Mgr. Anthony Sabadini Title: Admin. Manager for Research, REU Date: 05/03/2021
The above is intended to describe the general contents and requirements of work being performed by people assigned to this classification. It is not intended to be construed as an exhaustive statement of all duties, responsibilities or skills of personnel so classified.
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