Associate Scientist, Upstream Process Development
Site Name: USA - Pennsylvania - King of Prussia Posted Date: Feb 10 2021 GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. Biopharm Process Development is a highly experienced Chemistry, Manufacturing and Controls (CMC) organization accountable for delivering robust, cost effective and competitive products and manufacturing processes spanning the full life-cycle of asset development from Discovery through commercialization. These activities are delivered through state-of-the art internal facilities as well as strategic external partners. Collectively, the team is accountable for CMC activities encompassing cell line development, cell culture/ microbial fermentation, purification development, and drug product/ device development. We also pioneer innovative technologies to improve robustness, reduce cost of goods, and improve the patient experience. Within Biopharm Process Development, the Microbial and Cell Culture Development department is responsible for the development of cell culture processes for the manufacture of GSK's Biopharm assets. The Department is also responsible for the scale-up and tech transfer of the processes to manufacturing facilities all over the world. Our aim is to integrate innovative expression and process platforms, automation and advanced data analytics into the upstream process development workflow. An opportunity has arisen for a process development scientist with ability to advance the perfusion platform and handle large sets of complex data. He/she will have the opportunity to develop new methods and build capability in automated workflows and data handling. In this role, you will be a member of a highly skilled team of scientists and engineers responsible for development and optimization of cell culture processes. The team will have access to the latest technology in small-scale as well as large scale bioreactors and analytical instruments. Although predominantly lab-based, the role also involves important aspects of verbal and written communication and requires good organisation skills as well as a broad scientific knowledge of cellular metabolism and physiology. You will be working in a matrix team and therefore the role will suit a scientist with good interpersonal skills, ability to solve complex problems, is self-motivated and has an open mindset. Key responsibilities include: Process development of perfusion-based cell culture processes and transfer to cGMP facilities. Execution of small-scale bioreactor studies for development and optimization of perfusion processes, evaluation for facility fit and small-scale model qualification. Interacting with colleagues in key partner groups: scientists/engineers involved in scale-up and tech transfer, downstream process development and analytical method development scientists, data scientists and statisticians. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Bachelor's or Master's degree in Bioprocess/Biochemical/Chemical Engineering or related Biological Science with up to 2 years industrial Experience working in a biological laboratory and familiarity with general laboratory procedures. Preferred Qualifications: If you have the following characteristics, it would be a plus: Demonstrated broad knowledge base in routine cell culture and sterile technique Excellent interpersonal and communication skills Ability to adapt quickly to new scientific areas and work across teams. Hands-on experience with mammalian cell culture procedures. Solid theoretical background in cell biology and physiology. Operation of automated small-scale bioreactors and/or bench-top reactors. Experience with perfusion processes. Writing and reviewing technical documents with a basic understanding of regulatory requirements Programming experience (e.g. Python, Matlab, Visual Basic, etc) Statistical analysis Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. gskbiopharm_development If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. 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