Site Name: USA - Maryland - Rockville Posted Date: Mar 10 2021 Are you energized by a challenging role in biology, where scientific demand is driving team growth? If so, this Downstream Scientist role would be a great opportunity to consider. The Early Development and SAM Center of Excellence, Technical Research & Development, GSK Vaccines is focused on developing vaccine candidates from discovery to development. We are looking for a motivated scientist with a strong experience in purification/downstream processes to contribute to the success of GSK vaccine platforms based on both novel mRNA technology and conventional recombinant antigen. This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following: Support development / optimization / validation of a commercial manufacturing process for the purification of mRNA and recombinant protein antigen. Independently design and execute laboratory experiments. Partner with diverse team members from various functions, multiple countries and members at various levels in organization. Benchmark specific technologies in own functional area to bring technology to state of the art. Solve complex problems through analytical thinking to identify and understand alternatives using knowledge gained through formal education, experience and sound judgment. Prepare oral and written reports to communicate scientific findings and to support project documentation and CMC submissions. Comply with data integrity requirements for laboratory work. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Degree in Biology, Biochemistry or Chemical Engineering or a related scientific field. BSc with 5+ years of experience or MS with 3+ years of experience or PhD with 1+ years of experience. Experience with different purification techniques such as chromatography and tangential flow filtration (TFF) and associated instrumentation such as Akta chromatography systems and Unicorn software. Experience with bioanalytical assays associated with purification processes, such as SDS-PAGE, Western blotting, HPLC, etc. Experience in research and development in a Biopharmaceutical industry or government laboratory setting is a must. Understanding of experimental design and be able to independently execute laboratory experiments. Preferred Qualifications: If you have the following characteristics, it would be a plus: Communicate effectively with regular verbal and formal updates to project teams and management. Understanding of purification of biologics, specifically large size mRNA, including process scale-up. Strong hands-on experience with a wide range of purification techniques for large nucleic acid molecules including affinity capture, ion exchange and hydrophobic interactions. Experience and understanding of nucleic acid analytical technologies. Understanding of Quality by Design and the development of a process control strategy. Design and execute DOE studies & high-throughput screen for purification process improvements and advancements including parameter optimization, scale-up, process window determination and process capability evaluation. Knowledge of technology transfer and GMP manufacturing. Be able to rapidly acquire project understanding and apply professional knowledge to project improvement. Demonstrated ability to efficiently work in a fast paced and fluid environment, changes in priority and timeline restrictions Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. *LI-GSK *This is a job description to aide in the job posting, but does not include all job evaluation details. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). 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