Scientist, Upstream Early Development, Early Development & SAM CoE, Technical R&D
Site Name: USA - Maryland - Rockville Posted Date: May 10 2021 As a Scientist, Upstream Early Development, you will play a key role as a process development expert working on innovative recombinant protein-based antigen expression projects and platforms. The position will combine lab-based experimental work (60%-70% of time) and project coordination within a cross-functional group of CMC scientists working on high impact and visibility vaccine programs. This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following: Kick-start design and development of Upstream processes for mammalian (primarily CHO) antigen expression projects in early stage. Facilitate process transfer to development units for late stage development/life cycle management in Global Drug Substance organization. Be responsible for breakthrough innovations in the CHO platform to develop and implement robust ‘technology of the future' scalable for clinical and commercial manufacturing Serve as a subject matter expert for Upstream process development, interface with Quality and Regulatory to support project documentation and CMC submissions. Developing and implementing of next generation upstream platform technologies for post approved vaccines programs as part of life cycle management. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Experiences in biology, biochemistry, chemical engineering, or other related areas. Solid experience in upstream process development for biologics or antigens expressed in CHO based systems. Experiences with upstream process development in shake flasks and small scale bioreactors Experience in planning, executing and performing data analysis using DoE, MVA and other advanced statistical approach. Preferred Qualifications: If you have the following characteristics, it would be a plus: Strong communication skills. Sound scientific methodology, critical thinking and problem solving skills. Ability to work in multidisciplinary environment. Experience in media and feed optimization and metabolite analysis, as well as metabolic modeling. Hands-on experience with mini-bioreactors (ambr15/250), Single Use Bioreactors, and High Throughput screening. Prior experience in the vaccine development and manufacturing. Knowledge and experience of state-of-the-art upstream processes and technologies, such as continuous manufacturing and PAT.Solid understanding of Quality by Design approach and deliverables Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. *LI-GSK *This is a job description to aide in the job posting, but does not include all job evaluation details. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). 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