Senior Scientist, Mass Spectrometry

Andover, Massachusetts
June 06 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

The process and product development organization, Biotherapeutics Pharmaceutical Sciences, is seeking a Ph.D., M.S. or B.S. level candidate specializing in mRNA/DNA, lipid and/or protein, mass spectrometry (MS). As part of the Analytical Research and Development (ARD) group, the candidate will investigate, develop, and implement LC/MS, LC/MS/MS and/or MALDI-TOF MS-based strategies for the structural characterization and routine analysis of recombinant protein and mRNA therapeutics, including heightened product comparability exercises for clinical-stage materials. As such, candidates should have in-depth understanding and hands-on experience with the characterization of mRNA/DNA, vaccine, monoclonal antibody, and/or fusion protein modalities that includes commensurate technical knowledge and skills for the proper elucidation of component subunits, peptides, oligonucleotides, carbohydrates and/or small molecules such as lipids. Candidates should be comfortable working at the interface of analytical chemistry, biochemistry, cell biology, upstream/downstream bioprocessing, and quality control, as well as participating on cross-functional project teams and interacting with research teams, business units and commercial manufacturing sites. Excellent written and communication skills, effective time-management, an innovative spirit, and the ability and desire to work both independently and collaboratively in a multidisciplinary, fast-paced, team-oriented environment are essential for the position.


Extensive experience with well-established MS approaches and methods for the detailed structural analysis of therapeutics such as mRNA/DNA or proteins is required. Relevant experience with chromatographic and electrophoretic methods, micro-sample handling techniques, automation via liquid handling robotics, automated MS data analysis/report generation solutions, and software development is anticipated. The candidate will serve as a mass spectrometry, biochemistry, and heightened product characterization resource for the department and project teams, proactively keeping colleagues updated with current scientific trends and technical aspects from conferences, local meetings, and the literature. Furthermore, the candidate would have the opportunity to develop novel strategies and methods with the latest UHPLC and MS technologies for more informative and efficient product characterization and process monitoring. Lastly, the candidate will be encouraged to make scientific presentations both internally and externally, as well as publish manuscripts in peer-reviewed journals.

Technical Skills Requirements
  • Specialization in mRNA/DNA and/or protein mass spectrometry ( LC/MS, LC/MS/MS and/or MALDI-TOF MS) is required.
  • Extensive experience with well-established MS approaches and methods for the detailed structural analysis of mRNA/DNA and/or therapeutic proteins is required.
  • Understanding of the regulatory landscape for the biopharmaceutical industry is anticipated, in addition to the ability to author sections in regulatory documents and write responses to queries.
  • Familiarity with mRNA/DNA and fusion proteins is highly desired with respect to structural characterization approaches, challenges and gaps, and regulatory principles.
  • MS-based method development experience is highly desired for implementing more informative and efficient approaches to product characterization and process monitoring.
  • Support investigations with heightened characterization methodologies as appropriate to solve complex issues regarding assay performance, product quality attributes, and drug substance and drug product manufacturing.
  • Accountable for general laboratory upkeep, and instrument maintenance and performance assessments.


  • Candidates should have a B.S. with 7+ years of experience, M.S. with 5+ years of experience, or Ph.D. with 0-3 years of experience with a discipline in chemistry, biochemistry or related field.
  • Primary focus in protein and/or mRNA/DNA mass spectrometry, commensurate with graduate studies, postdoctoral research, and/or work experience.

  • Prior employment (including internships) in the pharmaceutical industry is highly desired, in addition to management experience of associate-level colleagues.

  • Position requires occasional light lifting and periods of standing, sitting or walking.
  • Ability to perform mathematical calculations and ability to perform complex data analysis.

  • Occasional work-related travel may be needed

Other Job Details:
  • Last Date to Apply for Job: June 25, 2021
  • Eligible for Employee Referral Bonus: YES


Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development