Senior Scientist

Boulder, Colorado
June 04 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist

This position will be reporting into the Molecular Pharmaceutics group at the Boulder Co location. The purpose of this position is to act as a resident pharmaceutical science subject matter expert to influence small molecule early drug candidate selectio n with respect to drug delivery , bio - performance , and stability . This position will close ly collaborat e with coll ea gues in Med icinal Chem istry, Pharmacokinetics & Drug Metabolism , and Clinical Pharmacology . This role will be responsible for designing, implementing, and interpreting in vitro , in silico , and in vivo experiments, as well as design of stage appropriate formulations for preclinical studies. An awareness of late stage drug product development , as well as an understanding of the disease state , drug target s and drug-target mechanism s of action , will help to enable and narrow the definition of the required design elements. In additional to formulation, this role will be responsible for material science and physicochemical properties assessments of early drug candidates . This includes laboratory measurements and interpretation of the data to inform manufacturing, bio-performance, and stability development risks.

  • E valuate the physicochemical properties of potential small molecule drug candidates to inform a drug product formulation strategy and developability risk assessment
  • Design and develop fit for purpose and diagnostic drug formulations for preclinical studies
  • Apply first principals understanding of thermodynamic s and kinetic processes to dissolution and precipitation of drugs in biorelevant conditions and physical state and chemical stability in the solid state.
  • Design, execute, and interpret the results of polymorph and salt screens for potential drug candidates related to stability, manufacturability, and bio-performanc e
  • Provide technical guidance for regulatory submissions
  • W ork in cross-disciplinary teams and partner with subject matter experts in Medicinal Chemistry , Pharmacokinetics & Drug Metabolism , and Clinical Pharmacology departments to influence candidate selection and progressio n . Develop strategic collaborations with academic and industrial researchers for addressing gaps in fundamental or applied science related to the pharmaceutical sciences
  • Conduct novel research and present significant findings via internal and external presentations or publications

  • PhD with 0 -3 year post-doctoral experience, MS with 5 + years experience, or BS with 8 + years experience in Chemical Engineering, Physical Chemistry, Biophysical Chemistry, Biophysics, Physics, Physical Organic Chemistry, Pharmaceutics, Pharmaceutical Sciences or Biochemistry
  • Candidates with experience in allied disciplines may also apply with the following qualifications: Ph.D. with minimum 3 years, MS with 7+ years, or BS with 12+ years of experience in industry
  • Experience working independently and collaboratively in a laboratory environment

  • Experience in breaking down and isolating the controlling physics of complex processes for experimental design
  • Experience in designing and conducting hypothesis driven laboratory experiments
  • G enerating , interpreting , and integrating experimental data into mathematical models to progress the understanding of complex materials and processes
  • Experience in pharmacokinetic modeling and simulations using Gastropl u s, Simcyp, or Phoenix
  • Experience with formulation design for preclinical studies as well as drug product design for phase 1 clinical trials
  • Strong organizational skills, interpersonal skills , teamwork skills, strong written and verbal communication skills
  • Ability to prioritize and manage multiple projects and activities while managing tight timelines


Includes activities in both laboratory and office settings; approximately 70%/30%. Candidate must be able to perform routine laboratory tests and procedures . Ability to perform mathematical calculations and ability to perform complex data analysis.


15 % travel (domestic and international)

  • Last Date to Apply: June 15, 2021
  • Eligible for relocation support
  • Eligible for employee referral bonus

For roles based in Colorado:

The annual base salary for this position ranges from $80.000 to $133,300 . In addition, this position offers an annual bonus with a target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.


Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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