Post-doctoral position in Molecular Imaging
Description: Post-doctoral positions are available for scientists with a background in biochemistry, chemistry, structural biology, molecular biology, or biology to perform cancer imaging research. Join a multi-disciplinary team in the emerging field of molecular imaging at the University of Michigan (https://sites.google.com/a/umich.edu/wang_lab). This highly collaborative group aims to develop innovative imaging technologies to monitor cancer therapy. Projects focus on the development, characterization, and validation of nanoparticles labeled with peptide ligands that bind cancer-specific targets, including 1) development of peptide heterodimers to produce multivalent ligand-target interactions for improved binding performance and detection of early targets at low levels of expression, 2) targeted nanocarriers for site-specific delivery with high payloads, low toxicity, and prolonged release, 3) use of sophisticated genomic tools to identify early targets that arise in the development of esophageal cancer, and 4) clinical translation of integrated imaging and therapeutic approaches. High resolution endoscopic, confocal, multiphoton, and photoacoustic imaging systems will be used to study small animal cancer models. Our goal is to perform cancer therapy in the biliary tract, colon, esophagus, head & neck, liver, pancreas, and stomach using advanced imaging methods to perform real-time monitoring. FDA-regulated clinical studies will be performed to validate peptide performance in human patients in collaboration with academic physicians. The University of Michigan is committed to diversity and equality in education and employment, and is an ideal training ground for postdocs who want to further develop their skills in pursuit of a career in academia or industry.
Requirements: Candidates with a Ph.D. in biochemistry, chemistry, structural biology, molecular biology, cell biology, genetics, microbiology, immunology, pharmacology, or related discipline are invited to apply. Experience in standard molecular biology techniques is desired, including cell culture, microscopy, flow cytometry, siRNA knockdown, structural protein modeling, ELISA, PCR, RT-PCR, Western blot, immunohistochemistry, and immunofluorescence. Experience with handling of small animals, including mice and rats, is desired. Salary is commensurate with training and experience.
Environment: The laboratory is located in the Biomedical Science Research Building (BSRB) between the University of Michigan Medical Center and the science campus. Pre-clinical studies are performed in the Center for Molecular Imaging (CMI) (https://cmi.med.umich.edu), and clinical trials are conducted in the hospital at the Medical Procedures Unit.
Contact: Candidates should submit CV and contact information by email: Thomas D. Wang, M.D.,Ph.D., Professor of Medicine, H. Marvin Pollard Collegiate Professor of Endoscopy Research, University of Michigan, Ann Arbor, MI 48109-2200, Email: firstname.lastname@example.org
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